Turinabol
Also known as: Tbol, 4-Chlorodehydromethyltestosterone, Oral Turinabol
Oral Anabolic Steroid | Lean Gains & Athletic Performance
Overview
Turinabol (4-chlorodehydromethyltestosterone) is a synthetic oral anabolic-androgenic steroid developed in the 1960s by Jenapharm, an East German pharmaceutical company. It was created by modifying the structure of methandrostenolone (Dianabol) with a 4-chloro substitution derived from clostebol, producing a compound with a significantly altered pharmacological profile. Turinabol became notorious as the cornerstone of East Germany's state-sponsored doping program (Staatsplan 14.25), which systematically administered the drug to thousands of Olympic athletes from the late 1960s through the 1980s, often without their knowledge. The 4-chloro modification prevents aromatization to estrogen, meaning turinabol does not cause water retention, gynecomastia, or other estrogen-related side effects. This made it particularly attractive for athletes in weight-class sports and those requiring speed, strength, and endurance without visible changes in body mass. Unlike many oral anabolic steroids, turinabol produces slow, steady, lean gains rather than rapid increases in size and strength. It has never been approved for medical use by the FDA or any current Western regulatory body, and it was withdrawn from the market following German reunification and the exposure of the East German doping program. Today it remains one of the most commonly detected substances in anti-doping testing due to the discovery of long-term metabolites detectable for many months after last use.
Key benefits
- Promotes lean, dry muscle gains without water retention or bloating
- Does not aromatize to estrogen, eliminating risk of gynecomastia and estrogen-related side effects
- Favorable anabolic-to-androgenic ratio, reducing androgenic side effects relative to muscle-building potential
- Enhances muscular endurance and recovery through increased red blood cell production
- Increases strength without significant body weight gain, beneficial for weight-class athletes
- Improves creatine phosphate resynthesis, supporting repeated high-intensity efforts
- Relatively mild androgenic profile compared to most oral anabolic steroids
- Produces slow, steady, maintainable gains rather than rapid temporary increases
Mechanism of action
Turinabol exerts its anabolic effects through binding to the intracellular androgen receptor (AR), promoting nitrogen retention, protein synthesis, and positive nitrogen balance in skeletal muscle. The 4-chloro substitution on the A-ring is the defining structural feature, serving two key pharmacological purposes: it completely prevents aromatization by the aromatase enzyme (blocking conversion to estrogenic metabolites), and it reduces the compound's androgenic potency relative to its anabolic activity. This results in a favorable anabolic-to-androgenic ratio, estimated at approximately 54:6 compared to methyltestosterone. Like other 17-alpha-alkylated steroids, turinabol resists first-pass hepatic metabolism, allowing oral bioavailability at the cost of increased hepatic stress. Turinabol enhances protein synthesis through AR-mediated gene transcription and increases red blood cell production, contributing to improved oxygen delivery and muscular endurance. It also promotes creatine phosphate synthesis within muscle cells, supporting ATP regeneration during high-intensity activity. The compound does not significantly interact with 5-alpha reductase, and its androgenic metabolites have low potency, contributing to its relatively mild androgenic side effect profile. It suppresses the hypothalamic-pituitary-gonadal (HPG) axis through negative feedback, reducing endogenous testosterone production in a dose-dependent manner.
Molecular data
- Type
- 17-alpha-alkylated anabolic-androgenic steroid (C20H27ClO2)
- Half-life
- ~16 hours
Indications
What the research community uses this compound for, with self-reported effectiveness.
Athletic Performance
Body Composition
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 30-40 mg/day | Split into 2 doses (morning and evening) | — |
| — | 40-60 mg/day | Split into 2 doses (morning and evening) | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Hepatic stress with elevated liver enzymes (ALT, AST) -- moderate severity, dose- and duration-dependent
- HDL cholesterol suppression (significant, often 30-50% reduction)
- LDL cholesterol elevation
- Suppression of endogenous testosterone production via HPG axis negative feedback
- Mild gastrointestinal discomfort or nausea
- Back pumps (lower back tightness during exercise, common with 17-alpha-alkylated compounds)
- Oily skin and mild acne
- Decreased appetite in some users
Rare side effects
- Significant hepatotoxicity or cholestatic jaundice (risk increases with doses above 60 mg/day or prolonged cycles)
- Hair thinning or acceleration of male pattern baldness (less common than with highly androgenic compounds)
- Virilization in women (deepening voice, hirsutism, menstrual irregularities)
- Tendon discomfort or injury with rapid strength increases
- Mood changes including irritability or low mood, particularly during suppression
- Peliosis hepatis (extremely rare, associated with prolonged high-dose use of 17-alpha-alkylated steroids)
Contraindications
- Known or suspected prostate cancer
- Breast cancer in males
- Pregnancy or planned pregnancy (teratogenic risk)
- Active liver disease or significant hepatic impairment
- Pre-existing severe dyslipidemia or cardiovascular disease
- Hypersensitivity to turinabol or related compounds
Monitoring
- Liver function tests (ALT, AST, bilirubin, ALP, GGT): baseline, 4 weeks, and end of cycle
- Lipid panel (total cholesterol, HDL, LDL, triglycerides): baseline, 4 weeks, and 4-6 weeks post-cycle
- Complete blood count: baseline and mid-cycle
- Total and free testosterone, LH, FSH: baseline and post-cycle to assess HPG recovery
- Blood pressure: regular monitoring throughout cycle
- Virilization assessment in female users at each follow-up
References
Primary literature and clinical-trial data informing this entry.