SupplementCycle

Frozen Shoulder

Adhesive capsulitis — painful, progressive shoulder stiffness where anti-inflammatory and repair peptides are explored.

Frozen shoulder (adhesive capsulitis) is driven by inflammation and fibrosis of the joint capsule, producing a painful loss of range that develops over months. The interest in peptides here is two-pronged: anti-inflammatory action during the painful 'freezing' phase, and tissue support through recovery.

BPC-157 and the anti-inflammatory peptide KPV are the usual candidates. There's essentially no controlled human data for frozen shoulder specifically, so this is educational only — the mainstays remain physiotherapy, and in some cases corticosteroid injection or hydrodilatation under a clinician.

Compounds researched

Ranked by editorial relevance — a measure of how central each compound is to the conversation, not a claim of effectiveness.

CompoundTypeWhy it's relevant
BPC-157peptideCytoprotective; explored for capsular repair.
KPVpeptideAnti-inflammatory alpha-MSH fragment for the painful phase.