BPC-157
Body Protection Compound-157 | Pentadecapeptide
Overview
Synthetic peptide derived from gastric juice protein, renowned for tissue repair, inflammation reduction, and GI protection capabilities. BPC-157 promotes blood vessel formation, enhances collagen synthesis, modulates growth factor expression, and protects against tissue damage through localized or systemic delivery.
Key benefits
- Accelerated tendon, ligament, muscle, and bone healing
- Localized tissue repair with direct targeting
- Superior bioavailability
- Anti-inflammatory effects
- Angiogenesis promotion
- Gastric and intestinal protection
Mechanism of action
Promotes blood vessel formation (angiogenesis), enhances collagen synthesis, modulates growth factor expression including VEGF, and protects against tissue damage through localized or systemic delivery pathways.
Molecular data
- Type
- Pentadecapeptide
- Half-life
- <30 minutes
Sequence
Gly-Lys-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Indications
What the research community uses this compound for, with self-reported effectiveness.
Wound Healing
Tendon Healing
Most effectiveAccelerated tendon-to-bone healing with improved biomechanical properties; most effective with localized injection.
Muscle Recovery
Most effectiveEnhanced healing and reduced recovery following crush injuries and surgical procedures with direct tissue targeting.
Angiogenesis
EffectivePromotes blood vessel formation and improves vascularization through localized delivery.
Neurological
Neuroprotection
ModerateProtective effects against neurotoxic agents and ischemic brain injury models.
Spinal Cord Injury
ModerateImproved functional recovery and reduced tissue damage in spinal cord injury studies.
Peripheral Nerves
ModerateEnhanced peripheral nerve regeneration and functional recovery after injury.
Gastrointestinal
Ulcer Protection
Most effectiveProtective effects against gastric and duodenal ulcers through cytoprotective mechanisms.
Intestinal Repair
EffectiveAcceleration of intestinal healing with reduced inflammatory markers in IBD models.
Mucosal Healing
EffectiveEnhanced mucosal barrier function and accelerated epithelial regeneration.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Injectable
Most effective for localized healing when injected near injury site. Subcutaneous injection preferred for targeted tissue repair.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Tendon/Joint healing | 250-500 mcg | 1-2x daily | SubQ near injury |
| Serious injury | 500-1000 mcg | 2x daily | SubQ near injury |
| General healing | 250-500 mcg | 1-2x daily | SubQ or IM |
| Maintenance | 250 mcg | 1x daily | SubQ |
Preparation
You will need
- Bacteriostatic water (BAC)
- Insulin syringes (0.5-1 mL)
- Alcohol swabs
- Peptide vial
- Sterile work surface
Steps
- Clean work area and hands thoroughly
- Calculate required BAC water volume using calculator
- Draw BAC water into syringe
- Inject slowly down vial side (not directly onto powder)
- Gently swirl until dissolved (never shake)
- Store in refrigerator, use within 28 days
Work out the water volume and syringe units in the reconstitution calculator →
Oral
Effective for gastric and intestinal conditions. Higher doses required due to lower bioavailability.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Gastric protection | 500 mcg - 1 mg | 1-2x daily | Oral (empty stomach) |
| General healing | 1-2 mg | 1-2x daily | Oral (empty stomach) |
| Ulcer prevention | 500 mcg | 2x daily | Oral (empty stomach) |
| Maintenance | 500 mcg | 1x daily | Oral (empty stomach) |
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
TB-500
SynergisticComplementary healing mechanisms; often used together in the Wolverine Stack.
GHRP-6
CompatibleNo known negative interactions.
Ipamorelin
SynergisticBPC-157 increases GH receptor expression, amplifying growth hormone benefits.
CJC-1295
SynergisticBPC-157 upregulates GH receptors, enhancing effectiveness for tissue repair.
Melanotan II
CompatibleNo known interactions; different mechanisms and receptor targets.
AOD-9604
CompatibleSafe combination; different pathways. Often combined in regenerative protocols.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- Week 1-2
Reduced inflammation and pain at injection site
- Week 2-4
Improved healing rate and tissue repair
- Week 4-8
Maximum localized healing benefits
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Mild injection site redness
- Injection site irritation
- Possible mild digestive adjustment (oral)
Stop signs — stop and seek advice
- Persistent injection site reactions or infection signs
- Unusual swelling or rash around injection area
- Severe headaches or dizziness
- Allergic reactions
- Persistent or worsening digestive issues
Contraindications
- Active cancer (due to angiogenic effects)
- Pregnancy or breastfeeding
- Blood thinners (consult doctor due to angiogenesis)
- WADA prohibited for competitive athletes
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White, fluffy lyophilized powder (cake) filling vial bottom
- Crystal clear solution after reconstitution with no particles
- Intact vacuum seal on vial
Warning signs
- Slight clumping that dissolves with gentle swirling (acceptable from shipping)
Stop signs — don't use
- Collapsed, melted, or powder stuck to vial sides (heat exposure)
- Cloudy solution, particles, or precipitates after reconstitution
- Discoloration of powder
Recent research
Newer papers and trial readouts on file for this compound, with source and date.
July 2025 · HSS Journal
Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review
Systematic review of 36 studies (35 preclinical, 1 clinical) from 1993-2024 showing BPC-157 enhances GH receptor expression, promotes angiogenesis, and reduces inflammatory cytokines in musculoskeletal injuries.
January 2025 · Pharmaceuticals
Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review
Comprehensive review by Jozwiak et al. of biological activities, mechanisms, and therapeutic potential across multiple organ systems including tissue injury and inflammatory bowel disease.
March 2025 · Alternative Therapies in Health and Medicine
Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study
First human IV safety study showing no adverse effects at doses up to 20 mg in healthy adults, establishing initial human safety profile.
December 2022 · Frontiers in Pharmacology
Pharmacokinetics, Distribution, Metabolism, and Excretion of Body-Protective Compound 157
IM bioavailability 14-19% in rats, 45-51% in dogs; half-life less than 30 minutes; rapidly metabolized into small peptide fragments.
References
Primary literature and clinical-trial data informing this entry.
Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth
Staresinic, M., et al. · Journal of Orthopaedic Research · 2003
Superior tendon healing with improved biomechanical properties (increased load of failure and Young's modulus), enhanced tendon-to-bone integration, and stimulated tendocyte growth in rat models.
Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157
Staresinic, M., et al. · Journal of Orthopaedic Research · 2006
Accelerated quadriceps healing over 72-day period with improved biomechanics, walking recovery, muscle fiber regeneration with desmin positivity, and attenuated atrophy in rat models.
Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats
Perovic, D., et al. · Journal of Orthopaedic Surgery and Research · 2019
Significant functional recovery with improved motor function, resolved spasticity by day 15, and counteracted axonal necrosis, demyelination, and cyst formation across all stages of secondary injury.
BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection
Park, J.M., Lee, H.J., Sikiric, P., Hahm, K.B. · Current Pharmaceutical Design · 2020
Cytoprotective effects against NSAID-induced gastric and intestinal damage by stabilizing intestinal permeability and protecting mucosal barrier function across multiple epithelia.
Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation
Hsieh, M.J., et al. · Journal of Molecular Medicine · 2017
Pro-angiogenic effects via VEGFR2-Akt-eNOS signaling pathway activation, increased vessel density in vivo and in vitro, and accelerated blood flow recovery in ischemic rat hind limb model.
Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds
Xu, C., et al. · Regulatory Toxicology and Pharmacology · 2020
Well tolerated in mice, rats, rabbits, and dogs with no serious toxicity in single-dose, repeated-dose, local tolerance, genetic, or embryo-fetal toxicity studies.
Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study
Lee, E., Walker, C., Ayadi, B. · Alternative Therapies in Health and Medicine · 2024
Pilot human trial in 12 women (ages 39-76) with interstitial cystitis showed BPC-157 as a potential treatment for this disabling condition with no effective existing therapies.
Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study
Lee, E., Burgess, K. · Alternative Therapies in Health and Medicine · 2025
First human IV safety data: infusions of up to 20 mg BPC-157 in 2 healthy adults showed no adverse effects on cardiac, hepatic, renal, thyroid, or glucose biomarkers.
Last updated . How this page was sourced is described in the methodology.
Featured in these stacks
- Classic Healing Stack (BPC-157 + TB-500)The best-known soft-tissue repair pairing — a cytoprotective peptide plus an actin-regulating one, for tendon, ligament, and muscle recovery.2 compounds
- Gut Repair (KPV + BPC-157)An anti-inflammatory gut-lining stack pairing the tripeptide KPV with cytoprotective BPC-157.2 compounds
- Joint & Tendon RebuildA connective-tissue stack pairing BPC-157 and TB-500 with GHK-Cu for collagen-focused joint and tendon repair.3 compounds
- Lean Preservation (Ostarine)A muscle-preservation stack built on the SARM ostarine, for protecting lean mass during a deficit or recovery.2 compounds
- Wound Healing TrioA three-peptide topical-and-systemic wound stack — antimicrobial LL-37 plus the BPC-157/GHK-Cu repair pair.3 compounds