SupplementCycle

Leaky Gut (Intestinal Permeability)

Increased intestinal permeability — the most common reason people look into gut-lining peptides.

'Leaky gut' (increased intestinal permeability) is where BPC-157 gets most of its gut-related attention: it was originally derived from a gastric protein and is most studied for gut-lining protection. KPV adds anti-inflammatory action relevant to inflamed mucosa.

The concept is more accepted in research than the term is in clinical practice. These are research compounds; persistent GI symptoms warrant a proper workup rather than self-treatment.

Compounds researched

Ranked by editorial relevance — a measure of how central each compound is to the conversation, not a claim of effectiveness.

CompoundTypeWhy it's relevant
BPC-157peptideGut-lining cytoprotection; the original use case.
KPVpeptideAnti-inflammatory for inflamed mucosa.