An upstream hormonal-axis stack using kisspeptin and gonadorelin to stimulate the HPTA at the hypothalamic level.
Kisspeptin acts upstream of GnRH, near the top of the reproductive axis, to stimulate the whole cascade — a more physiological 'kickstart' than acting at the testes. Gonadorelin (a GnRH analogue) adds direct pituitary stimulation.
This is a newer, more experimental approach to restarting or supporting the male hormonal axis than the classic SERM/hCG route. The human protocol data is thin, which the compound pages make clear.
| Compound | Role | Dose | Frequency |
|---|---|---|---|
| Kisspeptin Upstream of GnRH; stimulates the full axis. | Primary | 100-200 mcg per injection | Single dose for testing, or 2-3 times weekly (NEVER daily - causes desensitization) |
| Gonadorelin GnRH analogue; direct pituitary stimulation. | Support | 100-200 mcg for single injections; 5-20 mcg per pulse for pulsatile therapy | 2-3 times weekly for fertility/TRT support; every 90-120 minutes for pulsatile therapy; single dose for diagnostic |