PeptidePreclinical
Kisspeptin
Also known as: KP-10, KP-54, Metastin
KISS1 Gene Product | Reproductive Neuropeptide
Overview
Kisspeptin acts as a master regulator of the reproductive system, stimulating GnRH neurons essential for puberty, fertility, and reproductive function.
Key benefits
- Potent reproductive hormone stimulation (LH/FSH)
- Restoration of natural testosterone production
- Fertility enhancement
- Sexual function support
- Hypogonadism treatment potential
Mechanism of action
Binds to GPR54/KISS1R receptors on hypothalamic GnRH neurons, triggering pulsatile GnRH release, which stimulates pituitary LH/FSH secretion and gonadal steroid production.
Molecular data
- Type
- Neuropeptide family (RFamide)
- Half-life
- ~4 minutes (KP-10), ~28-32 minutes (KP-54)
Sequence
Kisspeptin-10: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Reproductive
Sexual Function
Metabolic
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100-200mcg | Single dose or 2-3x weekly | — |
| — | 0.4-1.0 nmol/kg (50-150mcg) | As directed by physician | — |
| — | 1 nmol/kg/h | 75-minute IV infusion | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 12.8 nmol/kg | Single dose | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Minimal acute side effects reported
- Potential mild cardiovascular effects
Contraindications
- Not recommended during pregnancy or breastfeeding
- Caution with cardiovascular disease history
- Daily dosing causes receptor desensitization
Monitoring
- Use sterile injection technique
- Avoid daily administration (maximum 2-3x/week)
- Monitor for ovarian hyperstimulation in women
- Consult reproductive endocrinologist for fertility use
References
Primary literature and clinical-trial data informing this entry.