Profound, persistent fatigue — where mitochondrial, immune, and low-dose naltrexone approaches are explored.
ME/CFS is a serious, poorly-understood condition of disabling fatigue and post-exertional malaise. Compound interest spans mitochondrial/energy support (NAD+, MOTS-c), immune modulation (thymosin alpha-1), and low-dose naltrexone for its neuro-inflammatory modulation.
There's no proven pharmacological cure, and aggressive exercise can worsen it. Everything here is exploratory; ME/CFS management belongs with a knowledgeable clinician, with pacing as a cornerstone.
Ranked by editorial relevance — a measure of how central each compound is to the conversation, not a claim of effectiveness.
| Compound | Type | Why it's relevant |
|---|---|---|
| NAD+ | peptide | Cellular-energy cofactor. |
| Naltrexone | supplement | Low-dose; neuro-inflammatory modulation. |
| MOTS-c | peptide | Mitochondrial peptide; energy support. |
| Thymosin Alpha 1 | peptide | Immune modulation where post-viral. |