Goals · Systems & Longevity
Cellular senescence, telomere health, mitochondrial function. The systemic healthspan play.
Compounds linked to this goal in the catalogue, ordered by role — primary, then support, then optional. Roles follow peptide-db's per-use effectiveness rating (most effective → primary, effective → support, moderate or thinner → optional); a compound that reaches the goal through a curated stack or a condition page says so. Click any card for the full mechanism, dosing, and evidence.
NNMT Inhibitor | Longevity & Metabolic Enhancement
Half-life: 4-7 hours (3.8h IV, 6.9h oral)
Synthetic Pineal Tetrapeptide | Telomerase Activator
Half-life: Not established (short peptide)
L-Glutathione | Master Antioxidant Tripeptide
Half-life: ~10-14 minutes (IV)
Mitochondrial-Targeted Peptide | Cardiolipin Protector
Half-life: ~2 hours
Thymic Peptide Bioregulator | Immune Modulator
Half-life: Not established (complex mixture); effects persist for weeks
Short-Acting Growth Hormone Releasing Hormone Analog
Half-life: 30 minutes - 2 hours
Support — Muscle Mass Preservation · effective
Senolytic Peptide | p53-FOXO4 Disruptor
Half-life: Not established
Support — Senescent Cell Clearance · effective
Copper Peptide | Skin Regeneration & Anti-Aging Compound
Half-life: 0.5-2 hours
Support — Researched for Skin Aging & Wrinkles
Mitochondria-Derived Peptide | HN
Half-life: ~30 minutes (mice), >4 hours (rats)
Support — Lifespan Extension · effective
KEDA Tetrapeptide | Liver Bioregulator
Half-life: Not established
Support — Chromatin Remodeling · effective
Mitochondrial-Derived Peptide | Metabolic Regulator
Half-life: ~30 minutes
Support — Age-Related Decline Reversal · effective
Essential Cellular Coenzyme & Anti-Aging Therapy
Half-life: 1-4 hours (intracellular)
Support — DNA Repair · effective
Anti-Cancer Peptide | p53-HDM-2 Disruptor
Half-life: Less than 24 hours (requires daily dosing in studies)
Support — Pancreatic Cancer · effective
KEDP Tetrapeptide | Prostate Bioregulator
Half-life: Not established
Support — Chromatin Remodeling · effective
Melanocortin Receptor Agonist | Sexual Dysfunction Treatment
Half-life: ~2.7 hours
Support — Sexual Distress Reduction · effective
GHRH Analog | Growth Hormone Releasing Hormone
Half-life: 10-12 minutes
Support — Age-Related GH Decline Reversal · effective
EW Dipeptide | Thymus Immune Bioregulator
Half-life: Not established
Support — Geroprotection · effective
KED | Vascular Bioregulator Peptide
Half-life: Not established
Support — SIRT1 Activation · effective
KE Dipeptide | Thymus Immune Bioregulator
Half-life: Not established
Support — Lifespan Extension · effective
Hair Growth Copper Peptide | Dermal Papilla Stimulator
Half-life: Not established
Optional — Researched for Skin Aging & Wrinkles
AEDL Tetrapeptide | Bronchial Bioregulator
Half-life: Minutes (short peptide); effects persist via epigenetic changes
Optional — Respiratory Aging · moderate
AEDR | Cardiovascular Bioregulator Peptide
Half-life: Minutes (short peptide); effects persist via epigenetic changes
Optional — Epigenetic Regulation · moderate
EDG Tripeptide | Bronchial/Lung Bioregulator
Half-life: Minutes (short peptide); effects persist via epigenetic changes
Optional — Geroprotection · moderate
Long-Acting Growth Hormone Releasing Hormone Analog | Extended Release
Half-life: 6-8 days
Optional — Recovery Enhancement · moderate
GHRH/GHRP Combination | Growth Hormone Optimization
Optional — Sleep Quality Enhancement · moderate
AEDP | Brain Cortex Bioregulator Peptide
Half-life: Minutes (short peptide); effects persist via epigenetic changes
Optional — Oxidative Balance · moderate
EDP Tripeptide | Thymus Immune Bioregulator
Half-life: Minutes (short peptide); effects persist via epigenetic changes
Optional — Tumor Cell Inhibition · moderate
Human Growth Hormone | Somatropin
Half-life: 3-4 hours (SC), 20-30 minutes (IV)
Optional — Skin and Hair Quality · moderate
Enhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection
Half-life: 2-10 hours
Optional — Researched for Age-Related Cognitive Decline
EDL Tripeptide | Liver & GI Bioregulator
Half-life: Not established
Optional — Liver Aging · moderate
KEDW Tetrapeptide | Pancreas Bioregulator
Half-life: Not established
Optional — Gene Expression Regulation · moderate
Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement
Half-life: Not established
Optional — Cellular Senescence Reduction · moderate
Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator
Half-life: Under investigation (no human PK data)
Optional — Mitochondrial Aging Reversal · moderate
Synthetic Thymic Hormone | Immune System Modulator
Half-life: ~2 hours
Optional — Thymic Regeneration Support · moderate
ED Dipeptide | Bladder & Urinary Tract Bioregulator
Half-life: Not established
Optional — Urogenital Aging · moderate
No SARMs tagged for this goal yet.
mTOR Inhibitor | Longevity & Immunosuppression
Half-life: ~62 hours
Biguanide | AMPK Activator & Longevity Research
Half-life: ~5 hours
Support — Cardiovascular Protection · effective
Mucolytic | Glutathione Precursor | FDA-Approved Drug
Half-life: ~6 hours (oral); plasma cysteine elevation persists ~12 hours
Support — Oxidative Stress Reduction · effective
NAD+ Precursor | Cellular Energy & Longevity
Half-life: ~2-3 hours (oral)
Support — NAD+ Restoration · effective
HMG-CoA Reductase Inhibitor | Low-Interaction Statin
Half-life: ~12 hours
Support — Primary Prevention of Cardiovascular Disease · effective
HMG-CoA Reductase Inhibitor | Statin for Lipid Management
Half-life: ~19 hours
Support — Primary Prevention in High-Risk Individuals · effective
Fast-Digesting Dairy Protein | Complete Amino Acid Profile
Half-life: Plasma amino-acid peak at ~60-90 minutes post-ingestion; aminoacidemia returns to baseline within 3-4 hours
Support — Sarcopenia Prevention · effective
Plant Alkaloid | Natural Glucose & Lipid Management
Half-life: ~4 hours
Optional — AMPK Activation / Metabolic Aging · under research
Mitochondrial Electron Carrier | Cognitive & Neuroprotection
Half-life: ~5-6 hours
Optional — Mitochondrial Dysfunction · moderate
Opioid Antagonist | Low-Dose Anti-Inflammatory & Immune Modulation
Half-life: ~4 hours
Optional — Researched for Chronic Fatigue Syndrome (ME/CFS)
Conditionally-Essential Amino Sulfonic Acid | Cardio & Mitochondrial Support
Half-life: ~1 hour (plasma) but tissue stores are large and slowly turn over
Optional — Insulin Sensitivity · moderate