NAD+
Also known as: Nicotinamide Adenine Dinucleotide, NAD
Essential Cellular Coenzyme & Anti-Aging Therapy
Overview
NAD+ is a crucial coenzyme found in every cell, involved in energy generation and cellular maintenance that naturally declines with age. Supplementation may support cellular health, boost energy, enhance cognitive function, and promote longevity through multiple delivery methods.
Key benefits
- Restores mitochondrial function and ATP synthesis
- Enhances glucose and fat metabolism
- Improves oxygen utilization and endurance
- Activates DNA repair mechanisms
- Supports longevity pathways via sirtuins
- Improves mental clarity and focus
Mechanism of action
Direct delivery to bloodstream ensures maximum cellular availability for energy production via ATP synthesis, DNA repair through PARP activation, and sirtuin-mediated longevity pathways. Supports mitochondrial function and metabolic homeostasis.
Molecular data
- Type
- Coenzyme
- Half-life
- 1-4 hours (intracellular)
Sequence
C21H27N7O14P2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Energy & Metabolism
Anti-Aging
Neurological
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 250-1000mg | 1-2x weekly | — |
| — | 100-500mg | 2-3x weekly | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100-500mg NMN or NR | Daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 25-50mg | 1-2x daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Mild flushing during IV infusion
- Temporary nausea
Rare side effects
- Injection site reactions
Contraindications
- IV administration requires medical supervision
- Avoid alcohol during treatment
- Maintain consistent dosing schedule
References
Primary literature and clinical-trial data informing this entry.
Featured in these stacks
- Anti-Aging BioregulatorsA bioregulator-style longevity stack pairing epitalon with NAD+ and MOTS-c for a multi-pathway approach.3 compounds
- Cellular Energy (NAD+)A mitochondrial-energy stack pairing injectable NAD+ with the mitochondrial peptide MOTS-c.2 compounds
- Longevity FoundationsA conservative anti-aging base pairing the pineal peptide epitalon with NAD+ for mitochondrial and cellular support.2 compounds