Blunted insulin sensitivity — the metabolic precursor where lifestyle compounds and incretins are explored.
Insulin resistance sits upstream of type 2 diabetes and metabolic syndrome. Interest spans the incretins (which improve insulin sensitivity), the supplement berberine (often compared to metformin for glycemic markers), and metformin itself.
The proven levers are weight loss, resistance training, and sleep — these compounds are adjuncts or, for the prescription agents, clinical tools. Educational only.
Ranked by editorial relevance — a measure of how central each compound is to the conversation, not a claim of effectiveness.
| Compound | Type | Why it's relevant |
|---|---|---|
| Metformin | supplement | Improves insulin sensitivity; well-studied. |
| Berberine | supplement | Supplement compared to metformin for glycemic markers. |
| Semaglutide | peptide | GLP-1; improves sensitivity via weight + direct effects. |