Goals · Systems & Longevity
Insulin sensitivity, glucose regulation, and energy metabolism.
Compounds linked to this goal in the catalogue, ordered by role — primary, then support, then optional. Roles follow peptide-db's per-use effectiveness rating (most effective → primary, effective → support, moderate or thinner → optional); a compound that reaches the goal through a curated stack or a condition page says so. Click any card for the full mechanism, dosing, and evidence.
5-Aminoimidazole-4-carboxamide Ribonucleotide | AMPK Activator
Half-life: ~2-3 hours
Long-Acting Amylin Receptor Agonist | Weight Loss & Diabetes
Half-life: ~7 days (159-195 hours)
Synthetic Pineal Tetrapeptide | Telomerase Activator
Half-life: Not established (short peptide)
Amino Acid Derivative | Fatty Acid Transporter
Half-life: ~2-3 hours (injectable)
Mitochondrial-Derived Peptide | Metabolic Regulator
Half-life: ~30 minutes
Essential Cellular Coenzyme & Anti-Aging Therapy
Half-life: 1-4 hours (intracellular)
Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator
Half-life: Under investigation (no human PK data)
Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes
Half-life: Approximately 6 days (109-115 hours)
Dual GIP/GLP-1 Receptor Agonist | Weight Loss & Diabetes
Half-life: ~5 days (120 hours)
NNMT Inhibitor | Longevity & Metabolic Enhancement
Half-life: 4-7 hours (3.8h IV, 6.9h oral)
Support — Energy Metabolism · effective
Mitochondrial Uncoupler | Metabolic Enhancer
Half-life: ~1.7 hours
Support — Obesity/Fat Loss · effective
GHRH/GHRP Combination | Growth Hormone Optimization
Support — Body Composition Support · effective
Examorelin | Synthetic Growth Hormone Secretagogue
Half-life: 1-2 hours
Support — Fat Metabolism · effective
KEDW Tetrapeptide | Pancreas Bioregulator
Half-life: Not established
Support — Impaired Glucose Tolerance · effective
GLP-1 Receptor Agonist | Weight Loss & Diabetes
Half-life: ~7 days (168 hours)
Support — Metabolic Syndrome Improvement · effective
Tesamorelin + Ipamorelin GH Secretagogue Blend
Support — IGF-1 Optimization · effective
GHRH Analog | Visceral Fat Reduction
Half-life: 26-38 minutes
Support — Triglyceride Reduction · effective
Vasoactive Intestinal Peptide | Neuropeptide
Half-life: 1-2 minutes
Support — Anti-Inflammatory · effective
Prohibitin-Targeting Peptidomimetic | Experimental Anti-Obesity
Half-life: Not established
Optional — Development halted after Phase 1 on kidney safety signals
IGF-1 Bioavailability Regulator & Neuroprotective Peptide
Half-life: Extended stability (more stable than linear GPE precursor)
Optional — Type-2 Diabetes · moderate
L-Glutathione | Master Antioxidant Tripeptide
Half-life: ~10-14 minutes (IV)
Optional — Researched for Non-Alcoholic Fatty Liver (NAFLD)
Modified Growth Factor Analog | Muscle Growth
Half-life: 20-30 hours
Optional — Nutrient Partitioning · moderate
KISS1 Gene Product | Reproductive Neuropeptide
Half-life: ~4 minutes (KP-10), ~28-32 minutes (KP-54)
Optional — Energy Metabolism · moderate
Synthetic Melanocortin Peptide | Tanning & Sexual Function
Half-life: ~2 hours
Optional — Appetite Suppression · moderate
No SARMs tagged for this goal yet.
Biguanide | AMPK Activator & Longevity Research
Half-life: ~5 hours
Conditionally-Essential Amino Sulfonic Acid | Cardio & Mitochondrial Support
Half-life: ~1 hour (plasma) but tissue stores are large and slowly turn over
Plant Alkaloid | Natural Glucose & Lipid Management
Half-life: ~4 hours
Support — Blood Glucose Management · effective
NAD+ Precursor | Cellular Energy & Longevity
Half-life: ~2-3 hours (oral)
Support — Mitochondrial Function · effective
Mucolytic | Glutathione Precursor | FDA-Approved Drug
Half-life: ~6 hours (oral); plasma cysteine elevation persists ~12 hours
Optional — Researched for Non-Alcoholic Fatty Liver (NAFLD)
Angiotensin II Receptor Blocker | Cardiac Protection On Cycle
Half-life: ~24 hours
Optional — Insulin Sensitivity Improvement · moderate
Fast-Digesting Dairy Protein | Complete Amino Acid Profile
Half-life: Plasma amino-acid peak at ~60-90 minutes post-ingestion; aminoacidemia returns to baseline within 3-4 hours
Optional — Satiety / Weight Management · moderate
Anabolic-Androgenic Steroid | Primary Male Sex Hormone
Half-life: ~8 days (cypionate)
Support — Insulin Sensitivity · effective