A gentle sleep stack pairing the delta-sleep-inducing peptide DSIP with well-tolerated supplement supports.
DSIP (delta-sleep-inducing peptide) is the peptide most associated with sleep-onset and slow-wave support, dosed once in the evening. It's the anchor here, with two low-risk supplement supports rounding it out.
Magnesium glycinate is a well-tolerated, evidence-supported mineral for sleep and relaxation; melatonin is a short-half-life signal that helps with sleep timing more than depth. Start with the supplements alone if you're new to this — they carry far less uncertainty than the peptide, which remains a research compound.
| Compound | Role | Dose | Frequency |
|---|---|---|---|
| DSIP Delta-sleep-inducing peptide; evening dose. | Primary | 100-300mcg | 1x daily |
| Magnesium Glycinate Well-tolerated relaxation/sleep mineral. | Support | 200-400 mg elemental magnesium per day | 1-2x daily, with food (evening for sleep applications) |
| Melatonin Sleep-timing signal; low dose is usually enough. | Optional | 0.3-3 mg (low-dose physiologic) or 5-10 mg (pharmacologic) — start low | 30-60 minutes before desired sleep onset |