DSIP
Also known as: Delta Sleep-Inducing Peptide
Delta Sleep-Inducing Peptide | Sleep & Stress Modulator
Overview
DSIP is a naturally occurring nonapeptide discovered in 1974 in rabbit brain. Originally isolated for sleep-promoting properties, it has diverse neuromodulatory effects including stress reduction, pain modulation, and endocrine regulation without traditional sedative effects.
Key benefits
- Enhanced sleep quality through slow-wave sleep promotion
- Stress reduction via cortisol modulation
- Potential pain relief
- Mood stabilization without traditional sedative effects
- No tolerance or dependence reported
- Short cycle duration (5-10 days)
Mechanism of action
Modulates multiple neurotransmitter systems including GABA enhancement, NMDA receptor interaction, and endogenous opioid system modulation. Also regulates hypothalamic-pituitary-adrenal axis for stress response.
Molecular data
- Type
- Nonapeptide
- Half-life
- ~15 minutes (in vitro)
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Indications
What the research community uses this compound for, with self-reported effectiveness.
Sleep
Mood
Pain & Recovery
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100-200mcg | Once nightly | — |
| — | 250-300mcg | Daily | — |
| — | 150mcg | Evening | — |
| — | 200-300mcg | Twice daily | — |
| — | 100-150mcg | Post-training | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 200-300mcg | Once at bedtime | — |
| — | 150-200mcg | Twice daily | — |
| — | 300-400mcg | Daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated with minimal side effects
- Mild drowsiness or dizziness initially (some users)
- Occasional headaches in sensitive individuals
- No tolerance or dependence reported in studies
Contraindications
- Avoid driving until effects are known
- Pregnancy or breastfeeding
Monitoring
- Monitor initial dose tolerance
- Track sleep quality improvements
- Watch for mood stability changes
References
Primary literature and clinical-trial data informing this entry.