Fat accumulation in the liver — where metabolic and antioxidant compounds are studied.
NAFLD (now often called MASLD) is closely tied to insulin resistance and visceral fat. The compounds of interest split between metabolic agents that reduce liver fat (GLP-1s, which show hepatic benefit) and antioxidant liver support (NAC, glutathione).
Weight loss is the single most effective intervention. These compounds are studied adjuncts; NAFLD with inflammation (NASH) is a progressing condition that needs hepatology follow-up, not self-management.
Ranked by editorial relevance — a measure of how central each compound is to the conversation, not a claim of effectiveness.
| Compound | Type | Why it's relevant |
|---|---|---|
| Semaglutide | peptide | GLP-1; reduces liver fat via weight + direct effects. |
| N-Acetylcysteine (NAC) | supplement | Glutathione precursor; antioxidant liver support. |
| Glutathione | peptide | Master antioxidant; hepatic relevance. |