Glutathione
Also known as: GSH, L-Glutathione, Reduced Glutathione, γ-glutamylcysteinylglycine
L-Glutathione | Master Antioxidant Tripeptide
Overview
Glutathione is the body's master antioxidant, a tripeptide produced naturally by the liver. It protects cells against free radicals, peroxides, and heavy metals while eliminating toxins including drugs and pollutants. Injectable glutathione bypasses gastrointestinal breakdown for superior bioavailability compared to oral supplements. Research supports benefits for neurological health, immune function, skin health, and anti-aging.
Key benefits
- Master antioxidant - protects against oxidative stress
- Detoxification of heavy metals and toxins
- Immune system support and T-cell function
- Neuroprotective effects
- Skin health and potential brightening effects
- Liver protection and function
- Mitochondrial support
- Anti-aging properties
Mechanism of action
Glutathione acts as the primary intracellular antioxidant, directly neutralizing reactive oxygen species and regenerating other antioxidants like vitamins C and E. It plays crucial roles in detoxification by conjugating with toxins for elimination, supports immune function through T-cell regulation, protects mitochondria, and maintains cellular redox balance. The thiol group of cysteine provides its antioxidant activity.
Molecular data
- Type
- Tripeptide
- Half-life
- ~10-14 minutes (IV)
Sequence
γ-Glu-Cys-Gly
Indications
What the research community uses this compound for, with self-reported effectiveness.
Antioxidant & Detox
Neurological
Immune & Skin
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100-200 mg | 2-3x weekly | — |
| — | 200-600 mg | 2-3x weekly | — |
| — | 600-1000 mg | Weekly IV | — |
| — | 1400 mg | 2-3x weekly | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 250-1000 mg | Daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Injection site reactions
- Mild nausea (usually with higher doses)
- Abdominal cramping
Rare side effects
- Allergic reactions
- Zinc depletion with long-term use
- Skin lightening (with high doses)
Contraindications
- Known allergy to glutathione
- Pregnancy or breastfeeding (insufficient safety data)
- Asthma (may trigger bronchospasm in some)
Monitoring
- Consider zinc supplementation with long-term use
- IV administration requires clinical supervision
References
Primary literature and clinical-trial data informing this entry.