HGH
Also known as: Somatropin, Somatotropin, rhGH, Recombinant Human Growth Hormone
Human Growth Hormone | Somatropin
Overview
Human Growth Hormone (HGH/Somatropin) is a 191-amino acid polypeptide hormone FDA-approved for pediatric and adult growth hormone deficiency, HIV-associated wasting, and other conditions. It provides both direct and indirect (IGF-1 mediated) anabolic effects.
Key benefits
- Improved body composition (increased lean mass, decreased fat)
- Enhanced bone mineral density
- Improved lipid profile
- Increased exercise capacity
- Better quality of life and mood
- Skin, hair, and nail improvements
- Enhanced recovery and healing
Mechanism of action
Binds to GH receptors on target tissues, triggering JAK2-STAT5 signaling pathway. Direct effects include lipolysis, protein synthesis, and metabolic regulation. Indirect effects via IGF-1 promote growth and anabolism. Half-life ~3 hours subcutaneously.
Molecular data
- Type
- Single-chain polypeptide with two disulfide bridges
- Half-life
- 3-4 hours (SC), 20-30 minutes (IV)
Indications
What the research community uses this compound for, with self-reported effectiveness.
Growth Hormone Deficiency
Body Composition
Anti-Aging
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 0.15-0.3mg/day (0.5-1 IU) | Once daily | — |
| — | 0.4-0.8mg/day (1.2-2.4 IU) | Once daily | — |
| — | 1-2 IU/day (0.33-0.67mg) | Once daily | — |
| — | 2-4 IU/day (0.67-1.33mg) | Once or twice daily | — |
| — | 4-8 IU/day (1.33-2.67mg) | Split twice daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Water retention and fluid accumulation
- Joint pain and stiffness
- Carpal tunnel syndrome (usually resolves with dose reduction)
- Headaches
- Numbness/tingling in hands
Contraindications
- Active cancer (may accelerate tumor growth)
- Acute critical illness (increased mortality in ICU patients)
- Closed epiphyses in children (for growth promotion)
- Pregnancy/breastfeeding
Monitoring
- Blood glucose - HGH causes insulin resistance and can unmask diabetes
- Thyroid function - can unmask hypothyroidism; may require T4 supplementation
- IGF-1 levels to assess dosing adequacy
- Intracranial pressure if headaches develop
References
Primary literature and clinical-trial data informing this entry.