5-Amino-1MQ
NNMT Inhibitor | Longevity & Metabolic Enhancement
Overview
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.
Key benefits
- Enhanced NAD+ levels
- Improved mitochondrial function
- Better energy metabolism
- Enhanced cellular repair
- Improved insulin sensitivity
- Longevity support
- Convenient daily oral dosing
Mechanism of action
Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.
Molecular data
- Type
- Small molecule NNMT enzyme inhibitor
- Half-life
- 4-7 hours (3.8h IV, 6.9h oral)
Indications
What the research community uses this compound for, with self-reported effectiveness.
Longevity
Metabolism
Weight Loss
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 25mg | 1x daily | — |
| — | 50mg | 1x daily | — |
| — | 75mg | 1x daily | — |
| — | 100mg | 1x daily | — |
| — | 50mg | 2x daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 150-250mcg | 1x daily | — |
| — | 250-500mcg | 1x daily | — |
| — | ~350mg (5mg/kg) | 1x daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally minimal side effects
- Occasional mild GI adjustment
- Potential sleep interference if dosed late in day
Contraindications
- Pregnancy or breastfeeding
- Pre-existing metabolic conditions (consult healthcare provider)
Monitoring
- Start with lowest effective dose (25-50mg) to assess tolerance
- Take with food to reduce potential GI effects
- Monitor energy levels and sleep quality
References
Primary literature and clinical-trial data informing this entry.
Featured in these stacks
- Metabolic & MitochondrialA mitochondrial-targeted metabolic stack built on MOTS-c, with 5-Amino-1MQ as an optional NNMT-inhibitor add-on.2 compounds
- Visceral Fat (Tesamorelin)A visceral-fat-targeted stack built on tesamorelin, the GHRH analogue FDA-approved for reducing visceral adipose tissue.2 compounds