Adamax
Next-Generation Semax Derivative | Nootropic Neuropeptide
Overview
Synthetic nootropic peptide with N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration, researched for cognitive enhancement, neuroprotection, and neuroplasticity.
Key benefits
- Enhanced cognitive function and mental clarity
- Improved focus and complex task handling
- Neuroprotection against oxidative stress
- Neuroplasticity support through BDNF upregulation
- Potential mood enhancement
- Stress resilience through HPA axis modulation
Mechanism of action
Crosses BBB via enhanced lipophilicity from adamantane; upregulates BDNF and TrkB receptor sensitivity; modulates dopamine, norepinephrine, and serotonin; stabilizes microtubules via ADNP-derived mechanisms; provides antioxidant and anti-inflammatory neuroprotection.
Molecular data
- Type
- Modified heptapeptide derivative
- Half-life
- 8-10 hours
Sequence
Ac-Met-Glu-His-Phe-Pro-Gly-Pro-AGly-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Cognitive
Neuroprotective
Mood
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 200-300mcg | 1x daily | — |
| — | 300mcg | 1-2x daily | — |
| — | 200mcg | 1x daily (morning) | — |
| — | 100-200mcg | 1x daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100-200mg | 1x daily (morning) | — |
| — | 100-200mg | 2x daily (morning, early afternoon) | — |
| — | 100mg | 1x daily (morning) | — |
| — | 100mg | 1x daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Headaches (particularly at higher doses)
- Insomnia or sleep disruption
- Anxiety or overstimulation
- Cardiovascular effects (elevated blood pressure, palpitations)
Contraindications
- Pregnancy and breastfeeding
- Cardiovascular conditions (without medical supervision)
- Severe anxiety disorders
- Uncontrolled hypertension
Monitoring
- Assess individual response at lower initial doses
- Monitor cardiovascular parameters
- Track tolerance development over cycling periods
- Observe for mood or sleep changes
- Use sterile injection technique to prevent infection
References
Primary literature and clinical-trial data informing this entry.