Adalank
Also known as: N-Acetyl Selank Amidate, ADA
N-Acetyl Selank Amidate | Enhanced Tuftsin Analog
Overview
Enhanced derivative of Selank with improved stability, blood-brain barrier penetration, and extended half-life compared to parent compound. Parent compound Selank approved in Russia since early 2000s.
Key benefits
- Potent anxiolytic effects without sedation
- Enhanced cognitive function
- Stress resilience
- Improved mood and emotional stability
- Neuroprotection via BDNF upregulation
- No tolerance, dependency, or withdrawal
Mechanism of action
Modulates GABAergic neurotransmission, upregulates hippocampal BDNF, influences serotonin metabolism, and provides immunomodulatory effects without benzodiazepine-like dependency.
Molecular data
- Type
- Modified heptapeptide
- Half-life
- Not established
Sequence
Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Anxiety
Generalized Anxiety Disorder
Most effectiveClinical trials showed effects comparable to benzodiazepines; 40% rapid response within 1-3 days.
Stress-Related Anxiety
Most effectiveReduces stress hormones and balances neurotransmitters without sedation.
Anxiety without Sedation
Most effectiveUnlike benzodiazepines, provides relief without tolerance, withdrawal, or dependency.
Cognitive
Cognitive Enhancement
EffectiveImproves focus, attention, and mental clarity.
Memory Protection
EffectiveBDNF-mediated neuroplasticity supports memory formation.
Neuroprotection
BDNF Upregulation
EffectiveRapidly elevates BDNF expression, supporting neuronal survival.
Stress Resilience
EffectiveEnhances ability to cope with psychological stress.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Injectable
Subcutaneous injection to belly, thigh, or upper arm. Morning administration aligns with cortisol rhythms.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Anxiety Reduction | 200-300mcg | 1x daily (morning) | SubQ |
| Cognitive Enhancement | 200-500mcg | 1x daily | SubQ |
| Stress Management | 200-300mcg | 2x daily (morning, afternoon) | SubQ |
| Initial Trial | 100-200mcg | 1x daily | SubQ |
Preparation
You will need
- Bacteriostatic water (BAC)
- Insulin syringes
- Alcohol swabs
- Sterile work surface
Steps
- Clean work area thoroughly
- Calculate BAC water volume
- Draw water into syringe
- Inject slowly down vial side (not directly onto powder)
- Gently swirl until dissolved (never shake vigorously)
- Store at 2-8°C
- Use within 14-30 days
Work out the water volume and syringe units in the reconstitution calculator →
Nasal
Intranasal spray for convenient administration.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Anxiety Management | 200-300mcg per dose | 2-3x daily (600-900mcg total) | Nasal spray |
| Initial Trial | 150-200mcg per dose | 2x daily | Nasal spray |
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
MAOIs
MonitorConsult healthcare provider; affects neurotransmitter systems.
Selank
CompatibleAdalank is enhanced derivative with improved stability and longer half-life.
Semax
CompatibleBoth are Russian nootropic peptides with different mechanisms.
BPC-157
CompatibleDifferent mechanisms; Adalank targets neurological pathways, BPC-157 focuses on tissue repair.
Diazepam
SynergisticEnhances benzodiazepine effects while reducing side effects in research studies.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- Days 1-3
40% may experience rapid anxiety reduction
- Week 1-2
Gradual anxiety relief, improved mood, enhanced stress resilience
- Week 2-4
Cognitive enhancement, improved focus, BDNF-mediated neuroplasticity
- Week 4+
Sustained anxiolytic and cognitive benefits
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Parent compound has high safety profile in Russian clinical research
- Minimal side effects reported
Stop signs — stop and seek advice
- Unusual or persistent headaches
- Significant mood changes or depression
- Unexpected sedation or extreme fatigue
- Unusual neurological symptoms
- Persistent injection site reactions or nasal irritation
- Severe gastrointestinal distress
Contraindications
- Experimental peptide with limited direct human research on N-Acetyl form
- Not recommended during pregnancy or breastfeeding
- Consult healthcare provider before use with psychiatric medications
Monitoring
- Use sterile injection technique
- Start with lower doses (100-200mcg) to assess response
- Cycle with 1-2 week breaks to prevent tolerance
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White, fluffy powder; proper freeze-drying indicated
- Clear solution after reconstitution; no particles or cloudiness
- Proper labeling with peptide name, batch number, manufacturing date
Warning signs
- Slight compaction from shipping acceptable if powder dissolves with gentle swirling
Stop signs — don't use
- Discoloration or yellowing indicates oxidation or degradation
- Persistent cloudiness or particles indicate degraded or contaminated peptide
References
Primary literature and clinical-trial data informing this entry.
Selank for GAD - Non-inferiority Trial
N/A
62 patients with GAD; 2700mcg/day intranasal; 14 days. Anxiolytic effects comparable to medazepam; 40% rapid response within 1-3 days.
Selank and BDNF Regulation in Hippocampus
N/A
Rat study; intranasal administration. Rapidly elevated BDNF expression, confirming neurotrophin involvement.
Peptide Selank Enhances Diazepam Effects
N/A
Rats in chronic mild stress model. Enhanced anxiolytic effects while reducing memory impairment and sedation.
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