PeptidePreclinical
SNAP-8
Also known as: Acetyl Octapeptide-3
Acetyl Octapeptide-3 | Anti-Wrinkle & Expression Line Peptide
Overview
Synthetic octapeptide functioning as topical Botox alternative, targeting dynamic facial wrinkles through SNARE complex modulation. Up to 63% wrinkle depth reduction demonstrated clinically.
Key benefits
- Non-invasive alternative to botulinum toxin
- Up to 63% wrinkle depth reduction demonstrated clinically
- Safe for sensitive periorbital areas
- No recovery time required
- Gradual, natural-appearing results
Mechanism of action
Mimics SNAP-25 protein N-terminal, competitively inhibits SNARE complex formation, reduces acetylcholine release at neuromuscular junctions.
Molecular data
- Type
- Acetylated octapeptide
- Half-life
- Not established (primarily topical use)
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Anti-Wrinkle
Muscle Relaxation
Skin Health
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 3-5% concentration | 2x daily | — |
| — | 5-10% concentration | 2x daily | — |
| — | 3-5% concentration | 2x daily | — |
| — | 3% concentration | 1-2x daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 0.33mg (330mcg) | 1x daily | — |
| — | 0.5mg (500mcg) | 1x daily | — |
| — | 1.0mg (1000mcg) | 1x daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Mild irritation or redness (especially at 5-10% concentrations initially)
- Minimal risk on sensitive periorbital areas
Contraindications
- Pregnancy and breastfeeding (insufficient safety data)
- Known peptide allergies
Monitoring
- Perform patch test on inner arm 24 hours before facial use
- Discontinue if persistent irritation occurs
- Avoid combining with strong acids in same application
References
Primary literature and clinical-trial data informing this entry.