AHK-Cu
Also known as: Copper Tripeptide-3, Alanine-Histidine-Lysine Copper Complex
Hair Growth Copper Peptide | Dermal Papilla Stimulator
Overview
Synthetic copper-binding tripeptide targeting dermal papilla cells and hair follicles. Stimulates hair follicle elongation, promotes cell proliferation, increases VEGF production, and inhibits TGF-β1. Supports skin regeneration through fibroblast activation and collagen synthesis.
Key benefits
- Hair follicle elongation stimulation
- Dermal papilla cell proliferation
- VEGF upregulation for improved scalp circulation
- TGF-β1 reduction (counters DHT effects)
- Anti-apoptotic protection for follicles
- Collagen synthesis support
- Convenient topical application
- Fibroblast activation for skin regeneration
Mechanism of action
AHK-Cu penetrates scalp delivering copper directly to dermal papilla cells. Activates proliferation pathways, elevates Bcl-2/Bax ratio (anti-apoptotic), increases VEGF for blood flow, reduces TGF-β1, and promotes SOD production for oxidative stress reduction.
Molecular data
- Type
- Copper tripeptide complex
- Half-life
- Not established
Sequence
L-Alanyl-L-Histidyl-L-Lysine (Ala-His-Lys)
Indications
What the research community uses this compound for, with self-reported effectiveness.
Hair Growth
Skin Regeneration
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 0.5-1% solution/serum | Once or twice daily | — |
| — | 0.3-0.5% AHK-Cu with minoxidil | Once or twice daily | — |
| — | 0.3-1% in serum/cream | Once or twice daily | — |
| — | Add 0.3-1% to water phase | Cool-down phase (<40°C) | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 0.1-0.5 mg per injection site | Weekly sessions | — |
| — | 1-5 mg | 2-3 times weekly | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated with excellent safety profile in topical applications
- Rare scalp irritation (patch test recommended)
- Potential for mild redness on sensitive skin
Contraindications
- Not for use on broken or infected skin
- Avoid eye area - may cause irritation
- Do not use if allergic to copper or peptides
- Not recommended during acute skin infections
Monitoring
- Avoid use with acidic products (AHAs, BHAs, Vitamin C) - use at different times
- Do not combine with additional copper supplements - risk of copper toxicity
- Keep pH between 5.5-7.0 for stability and skin compatibility
- Store properly - degrades with heat, light, and improper pH
- Patch test before full application if sensitive skin
References
Primary literature and clinical-trial data informing this entry.