Epitalon
Also known as: Epithalon, AEDG, Endoluten
Synthetic Pineal Tetrapeptide | Telomerase Activator
Overview
Epitalon is a synthetic tetrapeptide developed by Russian scientist Vladimir Khavinson with 35+ years of research. It activates telomerase at extremely low concentrations to maintain telomere length, stimulates melatonin production, and modulates gene expression through epigenetic mechanisms.
Key benefits
- Telomere extension and cellular replicative lifespan extension
- Enhanced melatonin production
- Improved immune function
- Potential lifespan extension (25-33% in animal studies)
- Systemic anti-aging through cellular rejuvenation
- Short cycle duration with long-lasting effects
Mechanism of action
Activates telomerase at extremely low concentrations (10⁻¹⁷ to 10⁻¹⁵ M) to maintain telomere length, stimulates melatonin production from the pineal gland, and modulates gene expression through epigenetic mechanisms.
Molecular data
- Type
- Tetrapeptide
- Half-life
- Not established (short peptide)
Sequence
Ala-Glu-Asp-Gly
Indications
What the research community uses this compound for, with self-reported effectiveness.
Anti-Aging
Neuroprotection
Immunity
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 200-500mcg | 1x daily for 10-20 days | — |
| — | 100mcg | 1x daily for 10-20 days | — |
| — | 300mcg | 1x daily for 10-20 days | — |
| — | 50mcg | 1x daily for 10-20 days | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 1-2mg daily (corrected from traditional 5mg) | 1x daily for 10-20 days | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 2-3mg | 2x daily for 10-20 days | — |
Protocol variations
Alternative cycling patterns reported in the literature and community.
Research-Based Low Dose
Based on actual human clinical trials, including a study of 75 women using 0.5mg/day sublingually for 20 days. Animal studies typically used 0.1-10mcg/mouse/day. This approach prioritizes evidence-based dosing over anecdotal community protocols.
High-Dose Community Protocol
Widely circulated protocol recommending 5-10mg daily injections. This dosing lacks peer-reviewed human clinical data and may stem from translation errors of Russian research or extrapolation from other peptides. No published studies validate this dose range in humans.
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated with minimal side effects
- Mild injection site reactions
- Vivid dreams (melatonin-related)
- Possible mild digestive upset (oral route)
Contraindications
- Active malignancy (telomerase activation concern)
- Chronic sinusitis (nasal route)
- Known peptide allergies
- Pregnancy or breastfeeding
Monitoring
- Skin changes and mole monitoring
- Sleep quality assessment
- Energy levels
- Optional: telomere length testing before/after cycles
References
Primary literature and clinical-trial data informing this entry.