Mazdutide
Also known as: IBI362, LY3305677
Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes
Overview
First-in-class dual GLP-1 and glucagon receptor agonist combining appetite suppression with thermogenesis stimulation. Phase 3 trials demonstrated superiority over semaglutide for weight loss and glycemic control.
Key benefits
- Up to 20% body weight loss
- Superior glycemic control versus semaglutide
- Increased energy expenditure via glucagon receptor activation
- Improved cardiometabolic markers (BP, lipids, liver fat)
- Once-weekly injection convenience
Mechanism of action
Dual agonist activation: GLP-1 stimulates insulin, suppresses glucagon, slows gastric emptying; Glucagon increases energy expenditure and thermogenesis while GLP-1 counteracts glucose-raising effects.
Molecular data
- Type
- Oxyntomodulin analog with fatty acid conjugation
- Half-life
- 6-8 days
Sequence
33-amino acid linear synthetic peptide
Indications
What the research community uses this compound for, with self-reported effectiveness.
Weight Loss
Type 2 Diabetes
Cardiovascular
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 1.5mg → 3mg | Once weekly | — |
| — | 1.5mg → 3mg → 4.5mg | Once weekly | — |
| — | 2mg → 4mg → 6mg | Once weekly | — |
| — | 3mg → 6mg → 9mg | Once weekly | — |
| — | 3-4.5mg weekly | Once weekly | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Nausea (mild-moderate, typically improves over time)
- Diarrhea
- Vomiting
- Increased heart rate (5-17 bpm observed)
Contraindications
- Personal or family history of medullary thyroid carcinoma
- MEN2 syndrome history (class warning for GLP-1 agonists)
- Pregnancy or breastfeeding (insufficient safety data)
Monitoring
- Start with lowest dose, escalate gradually every 4 weeks
- Monitor blood glucose if taking insulin or sulfonylureas
- Watch for pancreatitis symptoms
- Monitor thyroid function
- Maintain adequate hydration during initial weeks