Melanotan II
Also known as: MT-II, MT2
Synthetic Melanocortin Peptide | Tanning & Sexual Function
Overview
Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that activates melanocortin receptors throughout the body. MC1R activation triggers melanin production for tanning, while MC4R affects sexual arousal and appetite control.
Key benefits
- Rapid tanning without UV exposure
- Enhanced sexual function and libido
- Appetite suppression
- Improved mood via melanocortin activation
- Photoprotection through increased melanin
Mechanism of action
Binds to melanocortin receptors (MC1R for tanning, MC4R for sexual function and appetite) to stimulate melanin production, enhance libido, and suppress appetite through hypothalamic pathways.
Molecular data
- Type
- Synthetic alpha-MSH analog
- Half-life
- ~2 hours
Indications
What the research community uses this compound for, with self-reported effectiveness.
Skin Health
Sexual Health
Metabolic
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 0.25mg | 1x daily | — |
| — | 0.5-1mg | 2-3x weekly | — |
| — | 0.5-1mg | As needed | — |
| — | 0.1-0.25mg | Every other day | — |
| — | 0.5mg | 2x weekly | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 1-2mg | 1-2x daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 1-2mg/mL solution | 1-2x daily | — |
Protocol variations
Alternative cycling patterns reported in the literature and community.
Traditional Loading Protocol
A decade-old protocol involving daily injections at higher doses for 1-2 weeks before maintenance. This approach is associated with more side effects including nausea and increased freckling/mole development. Dosing on non-tanning days can lead to uneven pigmentation.
Pre-Tan Only Protocol
NEVER administer on non-tanning days. Always tan within 1 hour of injection. Start extremely low (50-75mcg) and increase by 25mcg every 3 sessions. This dramatically reduces freckling, uneven pigmentation, and side effects. The traditional loading phase is considered counterproductive - it builds melanin in areas with high melanocyte activity (freckles, moles, genitals) rather than where UV protection is needed.
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Nausea (pre-treatment with antiemetics recommended)
- Facial flushing
- Temporary blood pressure elevation
- Fatigue
- Spontaneous erections
Contraindications
- History of melanoma or dysplastic nevi
- Pregnancy or breastfeeding
- Cardiovascular conditions
- Uncontrolled hypertension
Monitoring
- Start with very low dose (0.1-0.25mg) to assess tolerance
- Monitor moles and freckles for any changes
- Stay hydrated to minimize headaches/flushing
- Regular skin examinations recommended
References
Primary literature and clinical-trial data informing this entry.