Sermorelin
Also known as: Sermorelin acetate, GHRH 1-29, Growth Hormone-Releasing Hormone
GHRH Analog | Growth Hormone Releasing Hormone
Overview
Sermorelin is a synthetic 29-amino acid analog of human growth hormone-releasing hormone that stimulates natural growth hormone production while preserving physiological pulsatile patterns. Originally FDA-approved in 1997 for pediatric GH deficiency, it was discontinued in 2008 for manufacturing reasons, not safety concerns.
Key benefits
- FDA-proven efficacy
- Maintains natural GH pulsatile patterns
- Preserves pituitary function
- 1.26kg lean mass increase documented in elderly
- IGF-1 mediated anabolic effects
- Allows natural feedback regulation
Mechanism of action
Subcutaneous injection provides optimal bioavailability for binding GHRH receptors, stimulating pulsatile GH release while maintaining hypothalamic-pituitary axis integrity and allowing natural somatostatin negative feedback.
Molecular data
- Type
- GHRH analog
- Half-life
- 10-12 minutes
Indications
What the research community uses this compound for, with self-reported effectiveness.
Muscle Growth
Anti-Aging
Hormonal
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 200-300mcg | Once at bedtime | — |
| — | 300-500mcg | Once at bedtime | — |
| — | 200mcg | 5 days weekly | — |
| — | 200mcg + GHRP | Once daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 30+ mcg/kg | Once daily at bedtime | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Injection site reactions (16.7% of patients - generally mild)
- Nasal irritation (intranasal route)
Contraindications
- Active malignancy
- Pituitary tumors
- Pregnancy
Monitoring
- Monitor thyroid function - 6.5% develop hypothyroidism requiring hormone replacement
- Check IGF-1 levels monthly initially, then every 3-6 months long-term
References
Primary literature and clinical-trial data informing this entry.