GHRP-2
Also known as: Pralmorelin, KP-102, GPA-748
Growth Hormone Releasing Peptide-2 | Pralmorelin
Overview
GHRP-2 is a synthetic growth hormone secretagogue that stimulates the pituitary gland to release growth hormone. It is one of the most potent members of the GHRP family, being 2-3 times more effective than GHRP-6 in stimulating GH release. Originally developed as a diagnostic agent for growth hormone deficiency, it works by mimicking ghrelin and binding to the GHS-R1a receptor.
Key benefits
- Potent stimulation of natural growth hormone release
- Enhanced muscle growth and recovery
- Improved body composition and fat metabolism
- Better sleep quality and recovery
- Increased appetite (can be beneficial for bulking)
- Maintains natural GH pulsatile release patterns
- Synergistic effects when combined with GHRH peptides
Mechanism of action
GHRP-2 acts as a synthetic agonist of ghrelin, binding to the growth hormone secretagogue receptor (GHS-R1a) in the hypothalamus and pituitary. This stimulates cAMP production and promotes pulsatile release of endogenous growth hormone without suppressing natural feedback loops. It works synergistically with GHRH to amplify GH secretion beyond what either peptide achieves alone.
Molecular data
- Type
- Synthetic hexapeptide
- Half-life
- ~30 minutes
Sequence
D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Growth Hormone Enhancement
Body Composition
Protective Effects
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100-150 mcg | 2-3x daily | — |
| — | 200-300 mcg | 2-3x daily | — |
| — | 100 mcg each | 2-3x daily | — |
| — | 100-200 mcg | Before bed | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Increased appetite (less than GHRP-6)
- Mild water retention
- Tingling or numbness in extremities
- Tiredness or lethargy after injection
- Mild headache
Rare side effects
- Elevated cortisol (with high doses)
- Elevated prolactin (with high doses)
Contraindications
- Active cancer or history of cancer
- Pregnancy or breastfeeding
- Pituitary disorders
- Diabetic retinopathy
- WADA prohibited for competitive athletes