VIP
Also known as: Vasoactive Intestinal Polypeptide, PHM-27
Vasoactive Intestinal Peptide | Neuropeptide
Overview
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. It is produced in many tissues including the gut, pancreas, and brain. VIP has potent vasodilatory, anti-inflammatory, and immunomodulatory effects. It binds to VPAC1 and VPAC2 receptors, triggering cAMP-mediated signaling cascades. Research shows therapeutic potential for pulmonary hypertension, diabetes, neurological disorders, and autoimmune conditions.
Key benefits
- Potent vasodilation and blood pressure reduction
- Strong anti-inflammatory effects
- Immunomodulation (Th1-Th2 balance)
- Neuroprotective effects
- Bronchodilation
- Cardioprotective (positive inotropic effects)
- Insulin secretion enhancement (glucose-dependent)
- Gut barrier and permeability regulation
Mechanism of action
VIP binds to VPAC1 and VPAC2 G protein-coupled receptors, activating adenylyl cyclase and increasing intracellular cAMP and PKA activity. This triggers phosphorylation of CREB and other transcription factors. VIP causes vasodilation through NO-dependent and independent mechanisms, stimulates intestinal secretion, relaxes smooth muscle, inhibits gastric acid secretion, and has positive inotropic/chronotropic cardiac effects.
Molecular data
- Type
- Neuropeptide
- Half-life
- 1-2 minutes
Sequence
His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Cardiovascular
Neurological
Metabolic & Immune
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 50-100 mcg | 1-2x daily | — |
| — | 100-200 mcg | As directed | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100-200 mcg/day | Daily (inhaled) | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Vasodilation (flushing, warmth)
- Hypotension
- Increased heart rate
- Gastrointestinal effects (diarrhea possible)
- Headache
Rare side effects
- Allergic reactions
- Excessive GI stimulation
Contraindications
- Severe hypotension
- VIPoma or related tumors
- Pregnancy or breastfeeding
- Severe cardiac conditions