Selank
Anxiolytic & Nootropic Peptide | Tuftsin Analog
Overview
Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences. It provides anxiolytic effects comparable to benzodiazepines but without sedation, amnesia, tolerance, or withdrawal.
Key benefits
- Rapid onset anxiolytic effects
- Enhanced BDNF expression (30% increase)
- Improved stress resilience
- Cognitive enhancement
- Immune modulation
- No tolerance or withdrawal
- Neuroprotective effects
Mechanism of action
Works through allosteric modulation of GABA-A receptors, serotonin and dopamine system optimization, enkephalin degradation inhibition, IL-6 and cytokine balance regulation, and BDNF upregulation in the hippocampus.
Molecular data
- Type
- Tuftsin analog
- Half-life
- 2-10 minutes
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Indications
What the research community uses this compound for, with self-reported effectiveness.
Anxiety
Cognitive
Immune
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 250mcg | 1x daily | — |
| — | 250mcg | 2x daily (morning & evening) | — |
| — | 500mcg | 1x daily (divided doses) | — |
| — | 250-350mcg | 1x daily (morning) | — |
| — | 250mcg | 2x daily | — |
| — | 250mcg | 1x daily for 2-4 weeks | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 300-600mcg (1-2 sprays) | Once daily or as-needed | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Minimal side effects - excellent safety profile
- No sedation or cognitive impairment
- No tolerance, dependence, or withdrawal
Contraindications
- Known peptide allergies
- Pregnancy or breastfeeding
- Consult healthcare provider with multiple psychiatric medications
Monitoring
- Start with lowest effective dose (250mcg)
- Refrigerate properly to maintain stability
- Use sterile injection techniques
- Monitor mood and anxiety levels
References
Primary literature and clinical-trial data informing this entry.