Cortagen
Also known as: AEDP, Ala-Glu-Asp-Pro, Brain Cortex Bioregulator
AEDP | Brain Cortex Bioregulator Peptide
Overview
Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it regulates inflammatory responses in the nervous system, restores balance between pro- and anti-oxidative processes, and stimulates interleukin-2 expression. Research shows potential benefits for ischemic brain injury recovery, nerve regeneration, and reducing autoimmune reactions affecting the CNS.
Key benefits
- Regulates central nervous system function
- Powerful anti-inflammatory effects in brain
- Supports nerve regeneration
- Restores oxidative balance
- Stimulates interleukin-2 expression
- Reduces autoimmune reactions
- Beneficial after ischemic brain injury
- Modulates gene expression in neural tissue
Mechanism of action
Cortagen works through epigenetic regulation by penetrating cell nuclei and interacting with DNA to modulate gene expression. In the heart, it affects genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15, and Eps15-rs. It powerfully regulates inflammatory responses in the nervous system, helping restore proper balance between oxidative and anti-oxidative processes. Cortagen stimulates IL-2 expression and helps regulate immune function, particularly by reducing autoimmune reactions.
Molecular data
- Type
- Tetrapeptide bioregulator
- Half-life
- Minutes (short peptide); effects persist via epigenetic changes
Sequence
Ala-Glu-Asp-Pro
Indications
What the research community uses this compound for, with self-reported effectiveness.
Neurological Support
Immune Regulation
Anti-Aging
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10-20 mg | Daily for 10-20 days | — |
| — | 10 mg | 2-3 cycles yearly | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10 mg | Daily for 10 days | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Contraindications
- Active neurological emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding