Pinealon
Also known as: EDR, Glu-Asp-Arg, Cerluten
Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement
Overview
Developed in Russia, Pinealon demonstrates unique DNA-interaction for neuroprotection and cognitive enhancement. Benefits traumatic brain injury recovery and age-related cognitive decline with excellent safety profile.
Key benefits
- Direct DNA interaction
- Neuroprotection
- Cognitive enhancement
- Excellent safety profile
- 40+ years of clinical use in Russia
Mechanism of action
Penetrates nuclear membranes to directly interact with DNA, modulates gene expression via histone H1.3 binding and MAPK/ERK pathway activation.
Molecular data
- Type
- Tripeptide
- Half-life
- Not established
Sequence
Glu-Asp-Arg (EDR)
Indications
What the research community uses this compound for, with self-reported effectiveness.
Neuroprotection
Traumatic Brain Injury
Most effectiveClinical protocol of 5mg daily showed significant cognitive improvements in 72-patient study.
Direct CNS Delivery
EffectiveSubcutaneous administration allows systemic circulation to brain tissue for neuroprotective effects.
Cellular Protection
EffectiveCaspase-3 suppression, ROS reduction, and excitotoxicity protection.
Cognitive
Memory Enhancement
EffectiveEnhanced neurotransmitter function with 1.9x serotonin increase in cell cultures.
NMDA Receptor Expression
Effective100 ng/kg optimal dose improved spatial learning in hippocampus.
Anti-Aging
Cellular Senescence Reduction
ModerateIrisin expression increases linked to telomere protection and mitochondrial enhancement.
Biological Age Markers
Moderate32-patient study showed significant improvements in aging indicators over 20-30 days.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Injectable
Highest bioavailability, direct systemic delivery, established clinical protocols.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Neuroprotection | 5mg daily | Once daily | SubQ |
| Cognitive Enhancement | 100-300mcg | Daily or every other day | SubQ |
| Anti-aging | 5mg | 20 days, 2-3x yearly | SubQ |
Preparation
You will need
- Lyophilized Pinealon powder
- Bacteriostatic water for injection
- Insulin syringes (30-31 gauge)
- Alcohol swabs
Steps
- Remove powder and water from refrigeration
- Clean vial tops with alcohol swabs; allow to dry
- Draw bacteriostatic water into syringe
- Inject water slowly down vial side to avoid foam
- Gently swirl until completely dissolved
- Store at 2-8°C
- Use within 30 days
Work out the water volume and syringe units in the reconstitution calculator →
Oral
Convenient, proven clinical efficacy. Ultra-short peptide structure survives gastric acid.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Cognitive Enhancement | 0.2mg twice daily | Morning and afternoon | Empty stomach |
| Sleep Support | 200mcg | Daily | Oral |
Nasal
Theoretical nose-to-brain delivery, potential rapid CNS access. Limited data available.
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
Melatonin
MonitorMonitor sleep patterns; Pinealon stimulates endogenous serotonin production.
Epitalon
SynergisticEnhanced neuroprotection through complementary telomerase activation pathways.
Cortexin
SynergisticSynergistic cognitive recovery in stroke patients through brain region targeting.
Thymalin
CompatibleSafe combination supporting neural-immune axis optimization.
BPC-157
CompatibleDifferent mechanisms with no known interactions.
NAD+
CompatibleComplementary anti-aging mechanisms.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- Week 1-2
Improved mental clarity and focus
- Week 2-3
Enhanced cognitive processing and memory
- Week 3-4
Peak neuroprotective and anti-aging benefits
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Minimal injection site reactions
- Mild gastrointestinal adjustment
- Occasional headache
- Fatigue
Stop signs — stop and seek advice
- Severe headaches or mood changes
- Persistent injection site reactions
- Signs of infection at injection site
- Unusual neurological symptoms
- Allergic reactions
Contraindications
- Pregnancy
- Lactation
Monitoring
- Medical supervision recommended
- Rotate injection sites
- Use sterile technique
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White crystalline powder; proper freeze-drying indicated
- Clear reconstituted solution; no particles or cloudiness
- Pharmaceutical packaging with batch numbers from reputable sources
Warning signs
- Ensure distinction between research (lab only) and pharmaceutical (human use) grade
Stop signs — don't use
- Discolored powder (yellow or brown) indicates degradation from heat or moisture
- Cloudy solution indicates contamination
References
Primary literature and clinical-trial data informing this entry.
Human Clinical Trial - Post-Traumatic Cerebrasthenia
2015
72 patients aged 30-74; 0.2mg twice daily; 20-30 days. Improved memory, reduced headache severity, and enhanced emotional stability compared to controls.
Aging Study - Polymorbidity Patients
2015
32 patients aged 41-83; variable dosing; 30 days. Significant improvements in biological aging biomarkers with anabolic effects.
Diabetic Rat Model - Spatial Learning
2020
100 ng/kg optimal dose; 14 days. Enhanced NMDA receptor expression in hippocampus with neuroplasticity improvements.
5xFAD Alzheimer's Mouse Model
2021
400 μg/kg IP daily; 28 days. Prevention of dendritic spine loss through MAPK/ERK pathway modulation.
Last updated . How this page was sourced is described in the methodology.