CJC-1295 (without DAC)
Also known as: Modified GRF 1-29, Mod GRF 1-29
Short-Acting Growth Hormone Releasing Hormone Analog
Overview
Synthetic growth hormone releasing hormone analog with short half-life enabling pulsatile GH secretion patterns resembling natural physiology. Unlike CJC-1295 with DAC, this version preserves natural GH pulsatility without continuous elevation.
Key benefits
- Preserves natural GH pulsatility
- Minimal side effects
- No receptor desensitization
- Precise GH release control
- 4x greater receptor affinity than native GHRH
Mechanism of action
Binds GHRH receptors on somatotroph cells in the pituitary gland, stimulating cAMP production and physiological GH pulses. The brief 30-minute half-life allows pulsatile release versus prolonged elevation.
Molecular data
- Type
- GHRH analog
- Half-life
- 30 minutes - 2 hours
Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys
Indications
What the research community uses this compound for, with self-reported effectiveness.
Growth Hormone
Anti-Aging
Recovery
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100mcg | 2x daily (morning and bedtime) | — |
| — | 100-150mcg | 3x daily (morning, post-workout, bedtime) | — |
| — | 200mcg | 2-3x daily with GHRP | — |
| — | 100-200mcg | Once at bedtime | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated at recommended doses
- Temporary facial flushing/warmth (5-10 minutes post-injection)
Contraindications
- Active cancer (due to growth-promoting effects)
- Diabetic retinopathy
- Severe kidney disease
- Pregnancy or breastfeeding
Monitoring
- Blood glucose if diabetic—GH affects insulin sensitivity
- Joint pain or carpal tunnel (excess GH indicator)
- Water retention lasting >2 weeks
References
Primary literature and clinical-trial data informing this entry.
Featured in these stacks
- Full GH-Axis StackA comprehensive growth-hormone-axis stack: CJC-1295 + ipamorelin pulse pairing with oral MK-677 for round-the-clock support.3 compounds
- GH-Fragment RecompA lipolysis-focused recomposition stack pairing the GH fragment AOD-9604 with the GHRH analogue CJC-1295.2 compounds
- Recomp GH SecretagogueA growth-hormone-axis stack for body recomposition — pulse-mimicking secretagogues rather than exogenous HGH.2 compounds