Hexarelin
Also known as: Examorelin, HEX, EP-23905
Examorelin | Synthetic Growth Hormone Secretagogue
Overview
Hexarelin is one of the most potent synthetic growth hormone secretagogues available. It stimulates GH release by binding to the GHS-R1a receptor in the pituitary and hypothalamus, mimicking the action of ghrelin. Notably, Hexarelin demonstrates synergistic effects when combined with GHRH, producing GH responses greater than the arithmetic sum of either peptide alone. It also shows unique cardioprotective properties mediated through the CD36 receptor.
Key benefits
- Most potent GHRP for GH stimulation
- Powerful synergy with GHRH peptides
- Cardioprotective effects via CD36 receptor
- Enhanced muscle growth and strength
- Improved fat metabolism
- Better recovery and tissue repair
- Maintains natural GH pulsatility
- Stable against proteolytic enzymes
Mechanism of action
Hexarelin binds to the growth hormone secretagogue receptor 1a (GHS-R1a) in the brain and pituitary gland. This binding initiates a signaling cascade that stimulates somatotroph cells in the anterior pituitary to produce and release growth hormone. Hexarelin also has slight, dose-dependent effects on prolactin, ACTH, and cortisol release. Its cardioprotective effects are mediated through CD36 receptor activation and modulation of calcium channels in cardiomyocytes.
Molecular data
- Type
- Synthetic hexapeptide
- Half-life
- 1-2 hours
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Growth Hormone Enhancement
GH Secretion
Most effectiveMost potent GHRP for stimulating endogenous growth hormone release from the pituitary.
Synergy with GHRH
Most effectiveProduces synergistic GH release when combined with GHRH, greater than sum of individual effects.
IGF-1 Elevation
EffectiveSignificant increases in IGF-1 levels through enhanced GH secretion.
Cardiovascular
Cardioprotection
EffectiveProtective effects on cardiac tissue mediated through CD36 receptor activation.
Cardiomyocyte Protection
ModerateReduces apoptosis of cardiomyocytes and controls cardiac action potential.
Calcium Channel Modulation
ModerateCardiotropic effects mediated by elevation of Ca2+ influx through voltage-gated calcium channels.
Metabolic
Fat Metabolism
EffectiveBeneficial effects on lipid metabolism via CD36 receptor in non-obese insulin-resistant models.
Body Composition
EffectiveImproved lean mass to fat ratio through GH and IGF-1 elevation.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Injectable
Subcutaneous or intramuscular injection. Hexarelin is rapidly absorbed after subcutaneous administration and demonstrates stability against proteolytic enzymes. Best administered on empty stomach.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| GH optimization | 100 mcg | 2-3x daily | SubQ or IM |
| Enhanced results | 200 mcg | 2-3x daily | SubQ or IM |
| With GHRH (synergy) | 100 mcg each | 2-3x daily | SubQ (combined) |
| Cardioprotection | 100-200 mcg | 1-2x daily | SubQ |
Preparation
You will need
- Bacteriostatic water (BAC)
- Insulin syringes (0.5-1 mL)
- Alcohol swabs
- Peptide vial
- Sterile work surface
Steps
- Clean work area and hands thoroughly
- Calculate required BAC water volume
- Draw BAC water into syringe
- Inject slowly down vial side (not directly onto powder)
- Gently swirl until dissolved (never shake)
- Store in refrigerator, use within 28 days
Work out the water volume and syringe units in the reconstitution calculator →
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
CJC-1295
SynergisticPowerful synergy; combination produces GH response greater than sum of individual effects.
GHRH 1-29
SynergisticResearch confirms synergistic GH release when co-administered.
GHRP-2
CompatibleSimilar mechanism; typically not stacked together but can be alternated.
GHRP-6
CompatibleSame receptor target; Hexarelin is more potent with less appetite stimulation.
Ipamorelin
CompatibleBoth are GHRPs; Hexarelin is more potent but may have more side effects.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- Immediately
GH spike within 15-30 minutes of injection
- Week 1-2
Improved sleep quality and recovery
- Week 2-4
Enhanced energy and well-being
- Week 4-8
Noticeable improvements in body composition
- Week 8-12
Maximum benefits; consider cycling to prevent desensitization
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Increased appetite (less than GHRP-6)
- Water retention
- Tingling or numbness
- Tiredness after injection
- Mild headache
Rare side effects
- Elevated cortisol levels
- Elevated prolactin levels
- Elevated ACTH levels
Stop signs — stop and seek advice
- Severe or persistent headaches
- Unusual swelling
- Signs of carpal tunnel syndrome
- Allergic reactions
Contraindications
- Active cancer or history of cancer
- Pregnancy or breastfeeding
- Pituitary disorders
- WADA prohibited for competitive athletes
Monitoring
- May cause receptor desensitization with prolonged use
- Consider cycling (8-12 weeks on, 4 weeks off)
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White to off-white lyophilized powder
- Clear solution after reconstitution
- Intact vacuum seal on vial
Warning signs
- Slight clumping that dissolves easily
Stop signs — don't use
- Discolored or yellow powder
- Cloudy solution after reconstitution
- Particles or precipitates in solution
References
Primary literature and clinical-trial data informing this entry.
Hexarelin Improves Lipid Metabolic Aberrations in Insulin-Resistant Mice
Endocrinology · 2017
Hexarelin treatment improved lipid metabolism via CD36 receptor in non-obese insulin-resistant MKR mice.
Effect of Repeated Hexarelin Administration on GH Responsivity
European Journal of Endocrinology · 1996
Demonstrated synergistic GH response when hexarelin co-administered with GHRH, greater than arithmetic sum.
Hexarelin Modulates GHS-R1a Expression
Neuroendocrinology · 2004
Hexarelin significantly increased pituitary and hypothalamic GHS-R1a mRNA levels.
Kinetics and Disposition of Hexarelin in Rats
Drug Metabolism and Disposition · 1999
Half-life of 75.9 min; rapidly absorbed subcutaneously; stable against proteolytic enzymes.
Last updated . How this page was sourced is described in the methodology.