Hexarelin
Also known as: Examorelin, HEX, EP-23905
Examorelin | Synthetic Growth Hormone Secretagogue
Overview
Hexarelin is one of the most potent synthetic growth hormone secretagogues available. It stimulates GH release by binding to the GHS-R1a receptor in the pituitary and hypothalamus, mimicking the action of ghrelin. Notably, Hexarelin demonstrates synergistic effects when combined with GHRH, producing GH responses greater than the arithmetic sum of either peptide alone. It also shows unique cardioprotective properties mediated through the CD36 receptor.
Key benefits
- Most potent GHRP for GH stimulation
- Powerful synergy with GHRH peptides
- Cardioprotective effects via CD36 receptor
- Enhanced muscle growth and strength
- Improved fat metabolism
- Better recovery and tissue repair
- Maintains natural GH pulsatility
- Stable against proteolytic enzymes
Mechanism of action
Hexarelin binds to the growth hormone secretagogue receptor 1a (GHS-R1a) in the brain and pituitary gland. This binding initiates a signaling cascade that stimulates somatotroph cells in the anterior pituitary to produce and release growth hormone. Hexarelin also has slight, dose-dependent effects on prolactin, ACTH, and cortisol release. Its cardioprotective effects are mediated through CD36 receptor activation and modulation of calcium channels in cardiomyocytes.
Molecular data
- Type
- Synthetic hexapeptide
- Half-life
- 1-2 hours
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Growth Hormone Enhancement
Cardiovascular
Metabolic
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100 mcg | 2-3x daily | — |
| — | 200 mcg | 2-3x daily | — |
| — | 100 mcg each | 2-3x daily | — |
| — | 100-200 mcg | 1-2x daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Increased appetite (less than GHRP-6)
- Water retention
- Tingling or numbness
- Tiredness after injection
- Mild headache
Rare side effects
- Elevated cortisol levels
- Elevated prolactin levels
- Elevated ACTH levels
Contraindications
- Active cancer or history of cancer
- Pregnancy or breastfeeding
- Pituitary disorders
- WADA prohibited for competitive athletes
Monitoring
- May cause receptor desensitization with prolonged use
- Consider cycling (8-12 weeks on, 4 weeks off)