MGF
Also known as: Mechano Growth Factor, IGF-1Ec, MGF-24aa-E
Mechano Growth Factor | IGF-1 Splice Variant
Overview
Non-pegylated IGF-1 splice variant produced locally in muscle tissue following mechanical stress. Has a very short half-life compared to PEG-MGF, requiring more frequent administration or localized injection.
Key benefits
- Satellite cell activation for muscle repair
- Recovery support following mechanical stress
- Localized tissue regeneration
- Natural upregulation after exercise
Mechanism of action
Activates muscle satellite stem cells via receptor binding, stimulating MAPK/ERK signaling. Enhances protein synthesis and promotes muscle fiber repair. The E-peptide domain exhibits distinct activity from mature IGF-1.
Molecular data
- Type
- IGF-1Ec splice variant C-terminal peptide
- Half-life
- ~5-7 minutes
Sequence
YQPPSTNKNTKSQRRKGSTFEEHK
Indications
What the research community uses this compound for, with self-reported effectiveness.
Muscle Repair
Tissue Regeneration
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 100-300mcg | Daily, post-workout | — |
| — | 100mcg → 300mcg | Daily, increasing weekly | — |
| — | 200-300mcg | Immediately post-workout | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Injection site soreness
- Mild fatigue
Contraindications
- Any history of cancer or neoplastic disease
- Pregnancy or breastfeeding
- Uncontrolled diabetes
Monitoring
- Not FDA-approved; limited human safety data
- Very short half-life requires precise timing
- Blood glucose monitoring recommended
- Prohibited in competitive sports (WADA banned)