PeptidePreclinical
PEG-MGF
Also known as: Pegylated MGF, MGF-24aa-E peptide
Pegylated Mechano Growth Factor | IGF-1 Splice Variant
Overview
Modified IGF-1 variant with PEG attachment extending half-life from minutes to hours. Activates muscle satellite cells following mechanical stress or injury.
Key benefits
- Extended half-life through PEGylation
- Satellite cell activation for muscle repair
- Recovery support following mechanical stress
- Potential neuroprotection against oxidative stress
Mechanism of action
Activates muscle satellite stem cells via receptor binding, stimulating MAPK/ERK signaling. Enhances protein synthesis and promotes muscle fiber repair. E-peptide domain exhibits distinct activity from mature IGF-1.
Molecular data
- Type
- IGF-1Ec splice variant C-terminal peptide
- Half-life
- 48-72 hours (via PEGylation)
Sequence
YQPPSTNKNTKSQRRKGSTFEEHK
Indications
What the research community uses this compound for, with self-reported effectiveness.
Muscle Repair
Tissue Regeneration
Recovery
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 200mcg | 2-3x weekly | — |
| — | 200-400mcg | Post-workout, 2-3x weekly | — |
| — | 200-400mcg | 2-3x weekly | — |
| — | 100-200mcg | 2x weekly | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Injection site soreness
- Mild fatigue
Contraindications
- Any history of cancer or neoplastic disease
- Pregnancy or breastfeeding
- Uncontrolled diabetes or severe hyperglycemia
Monitoring
- Not FDA-approved; limited human safety data available
- Long-term safety profile unknown
- Age-dependent response: benefits shown in young donors but not elderly
- Blood glucose monitoring recommended for diabetic individuals
- Prohibited in competitive sports (WADA banned)