NA-Selank Amidate
Also known as: N-Acetyl Selank Amidate, NASA, Enhanced Selank
N-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic
Overview
NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics. The N-acetyl group improves blood-brain barrier penetration and creates more stable metabolites, while the C-terminal amidation further enhances metabolic stability and receptor binding. Unlike benzodiazepines, it provides anxiety relief without sedation, dependency, or cognitive impairment.
Key benefits
- Pronounced anxiolytic effects without sedation
- Enhanced blood-brain barrier penetration (vs standard Selank)
- Improved metabolic stability and longer half-life
- Nootropic effects with enhanced memory and learning
- Increased BDNF levels for neuroplasticity
- No dependency or withdrawal effects
- Immune-modulating properties
- Effects persist after treatment cessation
Mechanism of action
NA-Selank Amidate modulates multiple neurotransmitter systems including GABA, dopamine, and serotonin, while regulating brain-derived neurotrophic factor (BDNF). It allosterically modulates GABAA receptors without causing the sedation or dependency of benzodiazepines. The peptide activates serotonin metabolism in the hypothalamus and brainstem, and increases BDNF levels to promote neuronal growth and differentiation.
Molecular data
- Type
- Modified heptapeptide
- Half-life
- 4-6 hours
Sequence
Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Anxiety & Mood
Generalized Anxiety
Most effectiveStandard Selank approved in Russia for GAD; NA-Selank Amidate offers enhanced delivery.
Stress Response
EffectiveModulates stress response through GABA and serotonin systems without sedation.
Mood Enhancement
EffectiveImproves mood through serotonin metabolism activation.
Cognitive Enhancement
Memory Enhancement
EffectiveIncreases memory trace stability for up to 30 days in animal studies.
Learning
EffectiveBDNF elevation supports learning and neuroplasticity.
Neuroprotection
ModerateBDNF increase reduces effects of neurological injury.
Immune Support
Immune Modulation
ModerateBased on tuftsin structure, retains immunomodulatory properties.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Nasal
Intranasal spray is the preferred delivery method, providing direct access to the brain while bypassing first-pass metabolism. The N-acetyl and amide modifications enhance absorption and stability.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Anxiety relief | 250-500 mcg | 1-2x daily | Intranasal |
| Cognitive enhancement | 200-400 mcg | 1-2x daily | Intranasal |
| Standard protocol | 300 mcg | 1-2x daily for 14 days | Intranasal |
Injectable
Subcutaneous injection is an alternative to intranasal delivery, though nasal spray is generally preferred for this peptide.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Alternative delivery | 250-500 mcg | 1-2x daily | SubQ |
Preparation
You will need
- Bacteriostatic water (BAC)
- Insulin syringes
- Alcohol swabs
- Peptide vial
- Sterile work surface
Steps
- Clean work area and hands thoroughly
- Calculate required BAC water volume
- Draw BAC water into syringe
- Inject slowly down vial side
- Gently swirl until dissolved (never shake)
- Store in refrigerator
Work out the water volume and syringe units in the reconstitution calculator →
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- Minutes to hours
Anxiolytic effects begin; reduced stress response
- Days 1-3
Nootropic effects become noticeable
- Week 1-2
Full anxiolytic and cognitive benefits
- Post-treatment
Benefits persist for approximately 1 week after 14-day course
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Mild nasal irritation (intranasal)
- Fatigue (rare)
Rare side effects
- Headache
- Dizziness
Stop signs — stop and seek advice
- Allergic reactions
- Paradoxical anxiety increase
- Unusual mood changes
Contraindications
- Pregnancy or breastfeeding
- Known hypersensitivity to Selank or tuftsin
- Severe psychiatric conditions (consult professional)
Monitoring
- Limit cycles to 2-3 weeks to prevent potential GABAergic desensitization
- Take breaks between cycles
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White to off-white lyophilized powder
- Clear solution after reconstitution
- Intact vacuum seal
Warning signs
- Slight clumping that dissolves easily
Stop signs — don't use
- Discolored powder
- Cloudy or particulate solution
- Unusual odor
References
Primary literature and clinical-trial data informing this entry.
Selank Administration Affects Expression of Genes in GABAergic Neurotransmission
Frontiers in Pharmacology · 2016
Selank modulates GABAA receptor activity, contributing to anxiolytic effects without benzodiazepine-like side effects.
Selank Clinical Trial in Anxiety Disorders
Zhurnal Nevrologii i Psikhiatrii · 2008
14 days of intranasal Selank produced pronounced anxiolytic and mild nootropic effects; benefits persisted 1 week post-treatment.
Selank and Serotonin Metabolism
Bulletin of Experimental Biology and Medicine · 2006
Single Selank injection activated serotonin metabolism and increased memory trace stability for up to 30 days.
Selank and BDNF Expression
Regulatory Peptides · 2009
Selank administration increases BDNF levels, supporting neuronal growth and memory enhancement.
Last updated . How this page was sourced is described in the methodology.