NA-Selank Amidate
Also known as: N-Acetyl Selank Amidate, NASA, Enhanced Selank
N-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic
Overview
NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics. The N-acetyl group improves blood-brain barrier penetration and creates more stable metabolites, while the C-terminal amidation further enhances metabolic stability and receptor binding. Unlike benzodiazepines, it provides anxiety relief without sedation, dependency, or cognitive impairment.
Key benefits
- Pronounced anxiolytic effects without sedation
- Enhanced blood-brain barrier penetration (vs standard Selank)
- Improved metabolic stability and longer half-life
- Nootropic effects with enhanced memory and learning
- Increased BDNF levels for neuroplasticity
- No dependency or withdrawal effects
- Immune-modulating properties
- Effects persist after treatment cessation
Mechanism of action
NA-Selank Amidate modulates multiple neurotransmitter systems including GABA, dopamine, and serotonin, while regulating brain-derived neurotrophic factor (BDNF). It allosterically modulates GABAA receptors without causing the sedation or dependency of benzodiazepines. The peptide activates serotonin metabolism in the hypothalamus and brainstem, and increases BDNF levels to promote neuronal growth and differentiation.
Molecular data
- Type
- Modified heptapeptide
- Half-life
- 4-6 hours
Sequence
Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Anxiety & Mood
Cognitive Enhancement
Immune Support
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 250-500 mcg | 1-2x daily | — |
| — | 200-400 mcg | 1-2x daily | — |
| — | 300 mcg | 1-2x daily for 14 days | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 250-500 mcg | 1-2x daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Mild nasal irritation (intranasal)
- Fatigue (rare)
Rare side effects
- Headache
- Dizziness
Contraindications
- Pregnancy or breastfeeding
- Known hypersensitivity to Selank or tuftsin
- Severe psychiatric conditions (consult professional)
Monitoring
- Limit cycles to 2-3 weeks to prevent potential GABAergic desensitization
- Take breaks between cycles