Dihexa
Also known as: N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
Synaptogenic Peptide | Cognitive Enhancement
Overview
Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis. It is 10 million times more potent than BDNF at promoting synapse formation through HGF/c-Met receptor activation.
Key benefits
- Dramatic synaptogenesis promotion
- 10 million times more potent than BDNF
- Cognitive enhancement and memory improvement
- Neuroprotection and potential neuroregeneration
- Applications for Alzheimer's, TBI, age-related cognitive decline
- Oral bioavailability
Mechanism of action
Binds to hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and potentiates its activity at c-Met receptor, activating PI3K/AKT pathways and promoting new synaptic connections with extraordinary potency.
Molecular data
- Type
- Modified oligopeptide
- Half-life
- 8-12 days
Sequence
Hexanoyl-Tyr-Ile-Ahx-NH2
Indications
What the research community uses this compound for, with self-reported effectiveness.
Cognitive
Neuroprotection
Neuroplasticity
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 8-10mg | 1x daily (morning) | — |
| — | 5mg | 1x daily | — |
| — | 10-15mg | 1x daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 0.5mg/kg daily | Daily or 3x weekly | — |
| — | 2-5mg total | 1x daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10-20mg cream | 1x daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Headaches (most frequent side effect)
- Anxiety or overstimulation
- Sleep disruption when dosed late in day
- Mental clarity increase
Contraindications
- Not FDA approved - research compound only
- Theoretical cancer risk via c-Met activation
- Cancer history (avoid due to c-Met pathway)
- Pregnancy or breastfeeding
- No long-term human safety data
Monitoring
- Cognitive function assessment
- Mood and anxiety levels
- Sleep quality
- Requires cycling to prevent tolerance
References
Primary literature and clinical-trial data informing this entry.