PeptidePreclinical
NA Semax Amidate
Also known as: N-Acetyl Semax Amidate
Enhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection
Overview
Enhanced and stabilized version of Russian nootropic Semax with superior stability, extended half-life, and enhanced bioavailability through acetylation and amidation modifications.
Key benefits
- Direct brain access via olfactory nerves
- Rapid onset (15-30 minutes)
- Proven cognitive efficacy
- Extended half-life vs standard Semax
- Enhanced BDNF upregulation
Mechanism of action
Bypasses blood-brain barrier via olfactory nerves with direct brain access; enhances BDNF upregulation and hippocampal plasticity.
Molecular data
- Type
- Modified ACTH analog
- Half-life
- 2-10 hours
Sequence
Asn-Ala-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂
Indications
What the research community uses this compound for, with self-reported effectiveness.
Cognitive
Neuroprotection
Memory
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 600mcg | 1x daily | — |
| — | 800mcg | 1x daily | — |
| — | 600mcg | 2x daily | — |
| — | 1200mcg | 1x daily | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 200mcg | 1x daily | — |
| — | 400mcg | 1x daily | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Mild nasal irritation (intranasal)
- Slight headache initially
Contraindications
- Not recommended during pregnancy
- Active nasal congestion or sinus infection
- Individuals on neurotransmitter-affecting medications without consultation
Monitoring
- Use sterile solutions only
- Start with lower doses
- Avoid if nasal congestion present
References
Primary literature and clinical-trial data informing this entry.