TB-500
Also known as: Thymosin Beta-4 Fragment, Ac-LKKTETQ
Synthetic Fragment (17-23) of Thymosin Beta-4
Overview
A synthetic 7-amino acid fragment corresponding to the actin-binding region of thymosin beta-4, originally developed for equine use with retained tissue repair properties. TB-500 acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation.
Key benefits
- Superior systemic tissue repair
- Accelerated muscle, tendon, and ligament healing
- Enhanced cell migration and angiogenesis
- Comprehensive regenerative effects
- Neuroprotective properties
Mechanism of action
Acts as principal actin-sequestering protein, regulating cell migration, promoting angiogenesis, reducing inflammation, and activating stem cell differentiation for comprehensive regenerative effects.
Molecular data
- Type
- Thymosin fragment
- Half-life
- ~2 hours
Sequence
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Indications
What the research community uses this compound for, with self-reported effectiveness.
Tissue Repair
Athletic Recovery
Neurological
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 2-3mg | 2x weekly | — |
| — | 4-5mg | 3x weekly | — |
| — | 2-3mg | 2x weekly | — |
| — | 3-4mg | 2-3x weekly | — |
| — | 2mg | 1-2x weekly | — |
| — | 3-5mg | 3x weekly | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 0.01-0.03% concentration | 1-2x daily | — |
| — | Eye drops formulation | As directed | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally minimal side effects
- Possible mild injection site reactions
- Temporary fatigue in some users
Contraindications
- Active cancer treatment (due to angiogenic effects)
- Pregnancy or breastfeeding
- Immunosuppressive medications (consult provider)
- WADA prohibited for competitive athletes
References
Primary literature and clinical-trial data informing this entry.
Featured in these stacks
- Classic Healing Stack (BPC-157 + TB-500)The best-known soft-tissue repair pairing — a cytoprotective peptide plus an actin-regulating one, for tendon, ligament, and muscle recovery.2 compounds
- Joint & Tendon RebuildA connective-tissue stack pairing BPC-157 and TB-500 with GHK-Cu for collagen-focused joint and tendon repair.3 compounds