Testagen
Also known as: KEDG, Lys-Glu-Asp-Gly, Testicular Bioregulator, Testes Peptide, Testoluten
KEDG Tetrapeptide | Testicular Bioregulator
Overview
Testagen is a Khavinson bioregulator tetrapeptide (KEDG) originally isolated from testicular tissue extracts. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it promotes testosterone biosynthesis by stimulating Leydig cell activity and improving cellular metabolism in testicular tissue. Research shows it helps restore normal communication within the hypothalamic-pituitary-gonadal (HPG) axis, governing testosterone production and spermatogenesis.
Key benefits
- Promotes testosterone biosynthesis
- Stimulates Leydig cell activity
- Improves testicular cellular metabolism
- Restores HPG axis communication
- Supports spermatogenesis
- Reduces prostatic inflammation
- Enhances male reproductive balance
- May normalize testosterone at any age
Mechanism of action
Testagen works through epigenetic regulation, crossing both cell and nuclear membranes to interact directly with DNA of target tissues. It penetrates into cytoplasm, nucleus, and nucleolus of cells, interacting with various cellular components including DNA and RNA. The peptide can discriminate between different nucleotide sequences and recognize cytosine methylation status. It interacts with the anterior pituitary gland and endocrine pathways involved in testosterone and TSH synthesis, restoring HPG axis communication.
Molecular data
- Type
- Tetrapeptide bioregulator
- Half-life
- Not established
Sequence
Lys-Glu-Asp-Gly
Indications
What the research community uses this compound for, with self-reported effectiveness.
Male Hormone Support
Male Reproductive Health
Prostate Support
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10-20 mg | Daily for 10-20 days | — |
| — | 10 mg | 2-3 cycles yearly | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10 mg | Daily for 10 days | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Contraindications
- Hormone-sensitive cancers (consult oncologist)
- Known hypersensitivity
- Female use not established
Monitoring
- Testosterone levels monitoring recommended
- PSA testing for men over 50