Vesugen
Also known as: KED, Lys-Glu-Asp, Vascular Bioregulator, Ventfort, Vezugen
KED | Vascular Bioregulator Peptide
Overview
Vesugen is a Khavinson bioregulator tripeptide developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology. Composed of three amino acids (lysine, glutamic acid, aspartic acid), it targets the vascular system and protects blood vessels from age-related decline. Research shows it limits atherosclerosis development, decreases endothelial dysfunction, and activates stem cells. Like other short Khavinson peptides, Vesugen penetrates to the nucleus where it influences gene expression.
Key benefits
- Protects vascular system from aging effects
- Limits atherosclerosis development
- Decreases endothelial cell dysfunction
- Activates SIRT1 anti-aging pathway
- Enhances stem cell proliferation
- Reduces cellular senescence markers
- Reverses SASP phenotype
- Works synergistically with Cardiogen
Mechanism of action
Vesugen works through epigenetic regulation by interacting with DNA promoter regions, particularly affecting Ki-67 gene expression which controls cell division. It plays a prominent role in regulating sirtuin 1 (SIRT1) protein levels - a key anti-aging protein activated during calorie restriction. Vesugen enhances mesenchymal stem cell proliferation, reduces senescence markers, improves cell differentiation, and may reverse the Senescence-Associated Secretory Phenotype (SASP) implicated in age-related cardiovascular disease.
Molecular data
- Type
- Tripeptide bioregulator
- Half-life
- Not established
Sequence
Lys-Glu-Asp
Indications
What the research community uses this compound for, with self-reported effectiveness.
Vascular Health
Vascular Aging
EffectiveProtects blood vessels from age-related deterioration through gene expression regulation.
Atherosclerosis Prevention
ModerateLimits development of atherosclerotic plaques in blood vessels.
Endothelial Function
ModerateDecreases endothelial dysfunction that contributes to cardiovascular disease.
Anti-Aging
SIRT1 Activation
EffectiveRegulates sirtuin 1 levels, mimicking some benefits of calorie restriction.
Stem Cell Activation
ModerateEnhances mesenchymal stem cell proliferation and reduces senescence.
Cellular Rejuvenation
ModerateReverses senescence-associated secretory phenotype in aging cells.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Oral
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Injectable
Injectable form available for direct administration, bypassing GI tract.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |
Preparation
You will need
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs
- Sterile vial
Steps
- Clean work area thoroughly
- Reconstitute with appropriate volume
- Gently swirl until dissolved
- Store reconstituted solution refrigerated
Work out the water volume and syringe units in the reconstitution calculator →
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
Cardiogen
SynergisticComplementary cardiovascular bioregulators - Vesugen for vessels, Cardiogen for heart tissue.
Epitalon
SynergisticOften combined in comprehensive anti-aging Khavinson protocols.
Thymalin
CompatibleDifferent organ targets; can be used in comprehensive bioregulator protocols.
Pinealon
CompatiblePart of Khavinson bioregulator family; targets different tissue.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- During cycle
Gene expression modulation and SIRT1 activation begins
- Post-cycle
Effects persist due to epigenetic changes
- Months
Vascular function improvements
- Long-term
Cumulative benefits with periodic cycles
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Stop signs — stop and seek advice
- Allergic reactions
- Unusual cardiovascular symptoms
Contraindications
- Active cardiovascular emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White powder or capsules
- Clear solution if reconstituted
- Proper packaging and labeling
Warning signs
- Unknown source or purity
Stop signs — don't use
- Discoloration
- Unusual odor
- Damaged packaging
References
Primary literature and clinical-trial data informing this entry.
Khavinson Peptide Bioregulators Research
Advances in Gerontology · 2020
Comprehensive review of bioregulator peptides including Vesugen and their epigenetic mechanisms.
Short Peptides and Vascular Aging
Bulletin of Experimental Biology and Medicine · 2018
Short peptides regulate sirtuin 1 levels and protect vascular tissue from aging.
Mesenchymal Stem Cell Activation by Peptide Bioregulators
Cell Technologies in Biology and Medicine · 2019
Vesugen enhances MSC proliferation and reduces senescence markers in stem cells.
Last updated . How this page was sourced is described in the methodology.