Vesugen
Also known as: KED, Lys-Glu-Asp, Vascular Bioregulator, Ventfort, Vezugen
KED | Vascular Bioregulator Peptide
Overview
Vesugen is a Khavinson bioregulator tripeptide developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology. Composed of three amino acids (lysine, glutamic acid, aspartic acid), it targets the vascular system and protects blood vessels from age-related decline. Research shows it limits atherosclerosis development, decreases endothelial dysfunction, and activates stem cells. Like other short Khavinson peptides, Vesugen penetrates to the nucleus where it influences gene expression.
Key benefits
- Protects vascular system from aging effects
- Limits atherosclerosis development
- Decreases endothelial cell dysfunction
- Activates SIRT1 anti-aging pathway
- Enhances stem cell proliferation
- Reduces cellular senescence markers
- Reverses SASP phenotype
- Works synergistically with Cardiogen
Mechanism of action
Vesugen works through epigenetic regulation by interacting with DNA promoter regions, particularly affecting Ki-67 gene expression which controls cell division. It plays a prominent role in regulating sirtuin 1 (SIRT1) protein levels - a key anti-aging protein activated during calorie restriction. Vesugen enhances mesenchymal stem cell proliferation, reduces senescence markers, improves cell differentiation, and may reverse the Senescence-Associated Secretory Phenotype (SASP) implicated in age-related cardiovascular disease.
Molecular data
- Type
- Tripeptide bioregulator
- Half-life
- Not established
Sequence
Lys-Glu-Asp
Indications
What the research community uses this compound for, with self-reported effectiveness.
Vascular Health
Anti-Aging
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10-20 mg | Daily for 10-20 days | — |
| — | 10 mg | 2-3 cycles yearly | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10 mg | Daily for 10 days | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Contraindications
- Active cardiovascular emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding