Chonluten
Also known as: EDG, Glu-Asp-Gly, T-34, Bronchial Bioregulator, Respiratory Peptide
EDG Tripeptide | Bronchial/Lung Bioregulator
Overview
Chonluten is a Khavinson bioregulator tripeptide (EDG) derived from respiratory lung tissue. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it targets the bronchopulmonary system with secondary activity in the GI tract. Research shows it regulates genes related to inflammation, antioxidant activity, and proliferation responses. Chonluten inhibits TNF production in monocytes and has been studied as a potential geroprotective agent that may support lung function in conditions like COPD.
Key benefits
- Normalizes respiratory system function
- Regulates protein synthesis in lung tissue
- Inhibits inflammatory TNF production
- Restores lung alveolar tissues
- Maintains bronchial mucous membranes
- Supports antioxidant gene expression
- May slow cell aging (geroprotective)
- Modulates mucosal function
Mechanism of action
Chonluten works through epigenetic regulation, penetrating cell and nuclear membranes to bind promoter or suppressor regions of DNA and modulate transcriptional control. It regulates genes including c-Fos, HSP70 (heat-shock protein), SOD (superoxide dismutase), COX-2, and TNF-alpha related to oxidative stress and proliferative regulation. The peptide inhibits TNF production in monocytes exposed to pro-inflammatory LPS, promoting attenuation of inflammatory action through TNF tolerance mechanisms.
Molecular data
- Type
- Tripeptide bioregulator
- Half-life
- Minutes (short peptide); effects persist via epigenetic changes
Sequence
Glu-Asp-Gly
Indications
What the research community uses this compound for, with self-reported effectiveness.
Respiratory Support
Bronchial Function
EffectiveNormalizes respiratory system function through gene expression regulation.
Lung Tissue Health
EffectiveRestores and maintains lung alveolar tissues and bronchial mucous membranes.
COPD Support
ModerateMay modulate mucosal function in chronic obstructive pulmonary disease.
Anti-Inflammatory
TNF Modulation
EffectiveInhibits TNF production in monocytes, reducing inflammatory responses.
Oxidative Stress
ModerateSupports SOD and antioxidant gene expression.
Anti-Aging
Geroprotection
ModerateResearched as potential agent that may slow cell aging.
Gene Expression Regulation
ModerateModulates c-Fos and proliferative gene activity.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Oral
Available in capsule form for oral administration. As a tripeptide, Chonluten has favorable permeability across cellular compartments. Typical protocol involves 10-20 day cycles.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Sublingual
Sublingual (lingual) form available for enhanced absorption.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Enhanced absorption | 10-20 mg | Daily for 10-20 days | Sublingual |
Injectable
Injectable form available for direct administration.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |
Preparation
You will need
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs
- Sterile vial
Steps
- Clean work area thoroughly
- Reconstitute with appropriate volume
- Gently swirl until dissolved
- Store reconstituted solution refrigerated
Work out the water volume and syringe units in the reconstitution calculator →
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
Bronchogen
SynergisticRelated respiratory bioregulators; complementary mechanisms.
Epitalon
SynergisticOften combined in comprehensive anti-aging Khavinson protocols.
Crystagen
CompatibleBoth have immune-modulating properties; different tissue targets.
BPC-157
CompatibleBoth support mucosal health through different mechanisms.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- During cycle
Gene expression modulation and anti-inflammatory effects begin
- Post-cycle
Effects persist due to epigenetic changes
- Weeks-Months
Respiratory function improvements
- Long-term
Cumulative benefits with periodic cycles
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Stop signs — stop and seek advice
- Allergic reactions
- Unusual respiratory symptoms
Contraindications
- Active respiratory emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White powder or capsules
- Clear solution if reconstituted
- Proper packaging and labeling
Warning signs
- Unknown source or purity
Stop signs — don't use
- Discoloration
- Unusual odor
- Damaged packaging
References
Primary literature and clinical-trial data informing this entry.
Peptides Regulating Proliferative Activity and Inflammatory Pathways in THP-1 Cells
PMC/NCBI · 2022
Chonluten tripeptide inhibits TNF production in monocytes exposed to pro-inflammatory LPS.
Chonluten and Gene Expression Regulation
Advances in Gerontology · 2018
Chonluten regulates c-Fos, HSP70, SOD, COX-2, and TNF-alpha gene expression.
Bronchial Bioregulator Peptides
Bulletin of Experimental Biology and Medicine · 2016
Short peptides derived from bronchial tissue regulate protein synthesis in lung cells.
Khavinson Peptide Bioregulators
Advances in Gerontology · 2020
Comprehensive review of bioregulator peptides including Chonluten and their mechanisms.
Last updated . How this page was sourced is described in the methodology.