Crystagen
Also known as: EDP, Glu-Asp-Pro, Thymus Tripeptide, Immune Bioregulator, Vladonix, Kristagen
EDP Tripeptide | Thymus Immune Bioregulator
Overview
Crystagen is a Khavinson bioregulator tripeptide (EDP) identified in thymalin with selective action on thymus tissues. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it enhances immune function by stimulating normal lymphocyte proliferation while inhibiting tumor cell growth. Research shows effectiveness in normalizing immunity in 82% of elderly patients (vs 56% control) and reducing respiratory infections in athletes by doubling HSP gene expression.
Key benefits
- Normalizes immune function in 82% of patients
- Stimulates normal lymphocyte proliferation
- Inhibits tumor cell growth (antitumor activity)
- Doubles HSP gene expression (stress resistance)
- Reduces respiratory viral infections
- Activates B-cell immune system
- Normalizes IL-6 expression
- Effective after radiation/chemotherapy
Mechanism of action
Crystagen works through epigenetic regulation by influencing gene expression and protein synthesis in immune cells. It regulates the synthesis of heat-shock proteins, cytokines, and affects cell differentiation, proliferation, and apoptosis. The EDP peptide enhances spontaneous proliferative activity of normal lymphocytes while inhibiting proliferation of tumor cells (K-562 erythromyelosis). It activates B-cell immune system and thymic epithelial cells (VTEC2.H/S).
Molecular data
- Type
- Tripeptide bioregulator
- Half-life
- Minutes (short peptide); effects persist via epigenetic changes
Sequence
Glu-Asp-Pro
Indications
What the research community uses this compound for, with self-reported effectiveness.
Immune Support
Stress Resistance
Anti-Tumor
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10-20 mg | Daily for 10-20 days | — |
| — | 10 mg | 2-3 cycles yearly | — |
| — | 10-20 mg | Daily during training cycles | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10 mg | Daily for 10 days | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Contraindications
- Active autoimmune flares (consult physician)
- Known hypersensitivity
- Pregnancy or breastfeeding