Vilon
Also known as: KE, Lys-Glu, Thymus Dipeptide, Immunget
KE Dipeptide | Thymus Immune Bioregulator
Overview
Vilon is a Khavinson bioregulator dipeptide (KE) consisting of lysine and glutamic acid, originally isolated from thymus gland extracts. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it acts as a molecular signaling compound that restores normal gene expression and protein synthesis in immune and epithelial cells. Research shows Vilon increases mean lifespan by 20-40% in animal studies and suppresses tumor development.
Key benefits
- Increases mean lifespan 20-40% in animal models
- Suppresses tumor development
- Stimulates thymocyte proliferation
- Activates T-helper cells
- Restores chromatin structure in aged lymphocytes
- Enhances intestinal barrier function
- Improves enzyme activity in aged tissue
- Part of comprehensive longevity protocols
Mechanism of action
Vilon works through epigenetic modulation, restoring chromatin structure and gene expression in immune cells. It stimulates thymocyte proliferation, activates T-helper cells, and increases the proliferative index in thymus tissue (from 26% to 37% in studies). The peptide modulates tyrosine phosphorylation of mitogen-activated cytoplasmic kinases and helps rejuvenate aged immune systems by restoring proper gene expression patterns.
Molecular data
- Type
- Dipeptide bioregulator
- Half-life
- Not established
Sequence
Lys-Glu
Indications
What the research community uses this compound for, with self-reported effectiveness.
Immune Support
Thymus Rejuvenation
EffectiveStimulates thymocyte proliferation and enlarges thymic lobules.
T-Cell Activation
EffectiveActivates T-helper cells and improves immune response.
Age-Related Immune Decline
EffectiveRestores chromatin structure and gene expression in aged lymphocytes.
Anti-Aging
Lifespan Extension
EffectiveLong-term treatment increased mean lifespan 20-40% in rodent studies.
Tumor Suppression
ModerateSuppresses development of spontaneous and induced tumors.
Tissue Regeneration
ModeratePromotes recovery in tissues exposed to radiation damage.
GI Health
Intestinal Function
ModerateRestores brush border membrane enzyme levels in aged animals.
Barrier Function
ModerateEnhances intestinal barrier function in aged rats.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Oral
Available in capsule form for oral administration. As the shortest Khavinson peptide (just 2 amino acids), Vilon is easily absorbed orally. Typical protocol involves 10-20 day cycles, repeated 2-3 times per year.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Injectable
Injectable form available for direct administration.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |
Preparation
You will need
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs
- Sterile vial
Steps
- Clean work area thoroughly
- Reconstitute with appropriate volume
- Gently swirl until dissolved
- Store reconstituted solution refrigerated
Work out the water volume and syringe units in the reconstitution calculator →
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
Thymalin
SynergisticBoth target thymus/immune system; complementary mechanisms.
Epitalon
SynergisticOften combined in comprehensive anti-aging Khavinson protocols.
Crystagen
SynergisticBoth have immunoprotecting properties; different mechanisms.
Thymogen
CompatibleRelated immune peptides; can be used in comprehensive protocols.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- During cycle
Immune activation and gene expression modulation begins
- Post-cycle
Effects persist due to epigenetic changes
- Weeks-Months
Immune function improvements
- Long-term
Cumulative benefits; longevity effects in animal models
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Stop signs — stop and seek advice
- Allergic reactions
- Unusual immune symptoms
Contraindications
- Active autoimmune flares (consult physician)
- Known hypersensitivity
- Pregnancy or breastfeeding
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White powder or capsules
- Clear solution if reconstituted
- Proper packaging and labeling
Warning signs
- Unknown source or purity
Stop signs — don't use
- Discoloration
- Unusual odor
- Damaged packaging
References
Primary literature and clinical-trial data informing this entry.
Peptide Bioregulators Increase Lifespan
Biogerontology · 2003
Long-term treatment with peptide preparations including Vilon increased mean lifespan 20-40% and suppressed tumorigenesis.
Vilon Effects on Aged Lymphocytes
Bulletin of Experimental Biology and Medicine · 2002
Vilon improved lymphocytes from old people by restoring chromatin structure and gene expression.
Peptides Regulating Proliferative Activity in THP-1 Cells
PMC · 2022
Vilon and other Khavinson peptides modulate key proliferative patterns and tyrosine phosphorylation of kinases.
Short Peptide Immunoprotecting Properties
Advances in Gerontology · 2018
Vilon and related peptides possess age-associated immunoprotecting properties in the spleen.
Last updated . How this page was sourced is described in the methodology.