Pancragen
Also known as: KEDW, Lys-Glu-Asp-Trp, Pancreas Bioregulator, Pancreatic Peptide, Suprefort
KEDW Tetrapeptide | Pancreas Bioregulator
Overview
Pancragen is a Khavinson bioregulator tetrapeptide (KEDW) originally isolated from bovine pancreatic cells. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it directly interacts with DNA to regulate pancreatic gene expression. Research in old rhesus monkeys demonstrated that Pancragen corrected impaired glucose tolerance, normalized insulin and C-peptide levels, and improved endocrine pancreatic function. It is considered safe and effective for age-related metabolic disturbances.
Key benefits
- Corrects impaired glucose tolerance
- Normalizes insulin levels
- Normalizes C-peptide levels
- Improves endocrine pancreatic function
- Supports pancreatic cell differentiation
- Regulates melatonin expression
- Reduces metabolic syndrome incidence
- Upregulates key pancreatic transcription factors
Mechanism of action
Pancragen works through epigenetic regulation by interacting with chromatin complexes and DNA structures to modulate pancreatic gene expression. Research shows it upregulates critical transcription factors for pancreatic cell maturation including Pdx1, Pax6, Ptf1a, Foxa2, Nkx2.2, and Pax4. Its small size (4 amino acids, ~576 Da) allows it to traverse cellular membranes and interact with nuclear components including histones and DNA.
Molecular data
- Type
- Tetrapeptide bioregulator
- Formula
- C26H36N6O9
- Half-life
- Not established
Sequence
Lys-Glu-Asp-Trp
Indications
What the research community uses this compound for, with self-reported effectiveness.
Metabolic Support
Impaired Glucose Tolerance
EffectiveCorrects age-related glucose tolerance disturbances in primate studies.
Metabolic Syndrome
ModerateReduces incidence and magnitude of metabolic syndrome.
Blood Sugar Regulation
ModerateHelps control blood sugar through pancreatic function support.
Pancreatic Health
Pancreatic Cell Differentiation
EffectiveImpacts differentiation of pancreatic cells during aging.
Endocrine Function
EffectiveImproves endocrine function of the pancreas.
Age-Related Pancreatic Decline
ModerateAddresses age-related imbalance of pancreatic function.
Anti-Aging
Gene Expression Regulation
ModerateDirectly interacts with DNA to regulate pancreatic gene expression.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Oral
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Injectable
Injectable form available for direct administration. Primate studies used intramuscular injection.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Research protocol | 0.05 mg/kg | Daily for 10 days | IM |
Preparation
You will need
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs
- Sterile vial
Steps
- Clean work area thoroughly
- Reconstitute with appropriate volume
- Gently swirl until dissolved
- Store reconstituted solution refrigerated
Work out the water volume and syringe units in the reconstitution calculator →
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
GLP-1 agonists
UnclassifiedBoth affect glucose metabolism; interaction unknown.
Epitalon
SynergisticOften combined in comprehensive anti-aging Khavinson protocols.
Livagen
CompatibleDifferent organ targets; can be used in comprehensive bioregulator protocols.
Vilon
CompatiblePart of Khavinson bioregulator family; targets different tissue.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- During cycle
Gene expression modulation begins
- Post-cycle
Effects persist due to epigenetic changes
- Weeks-Months
Glucose tolerance and pancreatic function improvements
- Long-term
Cumulative benefits with periodic cycles
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Stop signs — stop and seek advice
- Allergic reactions
- Unusual blood sugar changes
- Signs of hypoglycemia
Contraindications
- Active pancreatic emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding
- Type 1 diabetes (consult physician)
Monitoring
- Blood glucose monitoring recommended
- Consider HbA1c testing with long-term use
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White powder or capsules
- Clear solution if reconstituted
- Proper packaging and labeling
Warning signs
- Unknown source or purity
Stop signs — don't use
- Discoloration
- Unusual odor
- Damaged packaging
References
Primary literature and clinical-trial data informing this entry.
Correction of Impaired Glucose Tolerance Using Tetrapeptide (Pancragen) in Old Female Rhesus Monkeys
PubMed · 2017
Pancragen normalized insulin and C-peptide levels, suggesting recovery of disturbed glucose tolerance in old animals.
Tetrapeptide KEDW Interacts with DNA and Regulates Gene Expression
Bulletin of Experimental Biology and Medicine · 2015
KEDW directly interacts with DNA and regulates pancreatic gene expression.
Impacts of Pancragen on Differentiation of Pancreatic Cells During Aging
Bulletin of Experimental Biology and Medicine · 2013
Pancragen affects pancreatic cell differentiation during aging process.
Prospects of Using Pancragen for Metabolic Disorders in Elderly
Bulletin of Experimental Biology and Medicine · 2011
Pancragen shows promise for correction of metabolic disorders in elderly people.
Last updated . How this page was sourced is described in the methodology.