Pancragen
Also known as: KEDW, Lys-Glu-Asp-Trp, Pancreas Bioregulator, Pancreatic Peptide, Suprefort
KEDW Tetrapeptide | Pancreas Bioregulator
Overview
Pancragen is a Khavinson bioregulator tetrapeptide (KEDW) originally isolated from bovine pancreatic cells. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it directly interacts with DNA to regulate pancreatic gene expression. Research in old rhesus monkeys demonstrated that Pancragen corrected impaired glucose tolerance, normalized insulin and C-peptide levels, and improved endocrine pancreatic function. It is considered safe and effective for age-related metabolic disturbances.
Key benefits
- Corrects impaired glucose tolerance
- Normalizes insulin levels
- Normalizes C-peptide levels
- Improves endocrine pancreatic function
- Supports pancreatic cell differentiation
- Regulates melatonin expression
- Reduces metabolic syndrome incidence
- Upregulates key pancreatic transcription factors
Mechanism of action
Pancragen works through epigenetic regulation by interacting with chromatin complexes and DNA structures to modulate pancreatic gene expression. Research shows it upregulates critical transcription factors for pancreatic cell maturation including Pdx1, Pax6, Ptf1a, Foxa2, Nkx2.2, and Pax4. Its small size (4 amino acids, ~576 Da) allows it to traverse cellular membranes and interact with nuclear components including histones and DNA.
Molecular data
- Type
- Tetrapeptide bioregulator
- Formula
- C26H36N6O9
- Half-life
- Not established
Sequence
Lys-Glu-Asp-Trp
Indications
What the research community uses this compound for, with self-reported effectiveness.
Metabolic Support
Pancreatic Health
Anti-Aging
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 10-20 mg | Daily for 10-20 days | — |
| — | 10 mg | 2-3 cycles yearly | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 0.05 mg/kg | Daily for 10 days | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Contraindications
- Active pancreatic emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding
- Type 1 diabetes (consult physician)
Monitoring
- Blood glucose monitoring recommended
- Consider HbA1c testing with long-term use