Livagen
Also known as: KEDA, Lys-Glu-Asp-Ala, Liver Bioregulator, Hepatoprotective Peptide, Svetinorm
KEDA Tetrapeptide | Liver Bioregulator
Overview
Livagen is a Khavinson bioregulator tetrapeptide (KEDA) with significant hepatoprotective and immunomodulatory properties. Structurally similar to Epitalon, it normalizes immune and antioxidant status while restoring liver function in hepatitis conditions. Livagen is best known for its ability to decondense chromatin, activating silent genes including ribosomal genes to boost protein synthesis and cellular activity. Maximum protective effects occur during aging.
Key benefits
- Significant hepatoprotective properties
- Decondenses chromatin to activate genes
- Restores liver function in hepatitis
- Normalizes immune status
- Improves antioxidant status
- Activates ribosomal gene expression
- Maximum effects occur during aging
- Boosts protein synthesis and cell activity
Mechanism of action
Livagen works through direct effects on DNA structure and function. It decondenses chromatin (tightly packed DNA), increasing expression of certain genes and improving the 'youthful' profile of cells. The peptide activates multiple genes in lymphocytes, including previously silent ribosomal genes, boosting protein synthesis and cell activity. It exhibits hepatoprotective effects through normalizing immune and antioxidant status in liver tissue.
Molecular data
- Type
- Tetrapeptide bioregulator
- Half-life
- Not established
Sequence
Lys-Glu-Asp-Ala
Indications
What the research community uses this compound for, with self-reported effectiveness.
Liver Support
Hepatoprotection
EffectiveProtects liver tissue through normalizing immune and antioxidant status.
Hepatitis Support
EffectiveRestores liver functions in both acute and chronic hepatitis models.
Liver Fibrosis
ModerateShows protective properties in liver fibroid induration models.
Anti-Aging
Chromatin Remodeling
EffectiveDecondenses chromatin to restore youthful gene expression patterns.
Age-Related Liver Decline
EffectiveMaximum hepatoprotective effects occur during aging.
Gene Activation
ModerateActivates silent genes including ribosomal genes for improved protein synthesis.
Immune Support
Immunomodulation
ModerateNormalizes immune function alongside liver protective effects.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Oral
Available in capsule form for oral administration. Short peptides can be absorbed orally and reach target tissues. Typical protocol involves 10-20 day cycles, often repeated 2-3 times per year.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Injectable
Injectable form available for direct administration.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |
Preparation
You will need
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs
- Sterile vial
Steps
- Clean work area thoroughly
- Reconstitute with appropriate volume
- Gently swirl until dissolved
- Store reconstituted solution refrigerated
Work out the water volume and syringe units in the reconstitution calculator →
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
Epitalon
SynergisticStructurally similar; often combined in comprehensive anti-aging protocols.
Glutathione
SynergisticBoth support liver function and antioxidant status.
Ovagen
SynergisticComplementary liver bioregulators with different sequences.
Vilon
CompatibleDifferent organ targets; can be combined in bioregulator protocols.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- During cycle
Chromatin remodeling and gene expression changes begin
- Post-cycle
Effects persist due to epigenetic changes
- Weeks-Months
Liver function improvements
- Long-term
Cumulative benefits with periodic cycles
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Stop signs — stop and seek advice
- Allergic reactions
- Unusual liver symptoms
Contraindications
- Active liver emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White powder or capsules
- Clear solution if reconstituted
- Proper packaging and labeling
Warning signs
- Unknown source or purity
Stop signs — don't use
- Discoloration
- Unusual odor
- Damaged packaging
References
Primary literature and clinical-trial data informing this entry.
Influence of KEDA Tetrapeptide on Organism Physiological Function
Advances in Gerontology · 2020
KEDA exhibits hepatoprotective, immunomodulatory, and geroprotective properties with maximum effects during aging.
Effects of Livagen Peptide on Chromatin Activation in Lymphocytes from Old People
Bulletin of Experimental Biology and Medicine · 2002
Livagen activates chromatin decondensation and multiple genes in aged lymphocytes.
Hepatoprotective Properties of KEDA in Hepatitis Models
Experimental Biology and Medicine · 2018
KEDA normalizes immune and antioxidant status and restores liver functions in hepatitis.
Khavinson Peptide Bioregulators
Advances in Gerontology · 2020
Comprehensive review of bioregulator peptides and their epigenetic mechanisms.
Last updated . How this page was sourced is described in the methodology.