PT-141
Also known as: Bremelanotide, Vyleesi
Melanocortin Receptor Agonist | Sexual Dysfunction Treatment
Overview
FDA-approved melanocortin receptor agonist for treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. Works centrally in the nervous system to trigger sexual arousal pathways independent of vascular mechanisms, unlike traditional ED medications.
Key benefits
- FDA-approved pharmaceutical route
- Predictable absorption profile
- Effective for both male and female sexual dysfunction
- Works within 45 minutes
- Effective in PDE5 inhibitor-resistant cases
- Central mechanism (not dependent on blood flow)
Mechanism of action
Selectively activates melanocortin receptors (MC3R/MC4R) in the central nervous system, triggering sexual arousal pathways independent of peripheral vascular mechanisms. Works within 45 minutes with effects lasting 6-12 hours.
Molecular data
- Type
- Melanocortin receptor agonist
- Half-life
- ~2.7 hours
Indications
What the research community uses this compound for, with self-reported effectiveness.
Sexual Health
Quality of Life
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 1.75mg | As needed, max 1 dose/24hr | — |
| — | 1-2mg | As needed, 45-60min before activity | — |
| — | 0.75-1.25mg | As needed, max 1 dose/24hr | — |
| — | 0.5mg | Test dose for tolerance assessment | — |
Delivery method
| Protocol | Dose | Frequency | Duration |
|---|---|---|---|
| — | 1.5-2mg | As needed, 30-45min before | — |
| — | 1-1.5mg | As needed, max 1 dose/24hr | — |
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Nausea (40%)
- Flushing (20%)
- Headache (11%)
- Injection site reactions
Contraindications
- Uncontrolled hypertension
- Cardiovascular disease
- Use of nitrate medications
- Pregnancy or breastfeeding
Monitoring
- Blood pressure monitoring recommended
- Take anti-nausea medication 30 minutes prior if prone to nausea
- Avoid alcohol to minimize BP effects
References
Primary literature and clinical-trial data informing this entry.
Featured in these stacks
- Libido Support (PT-141)A centrally-acting desire stack built on PT-141 (bremelanotide), with an optional PDE5 inhibitor for the physical side.2 compounds
- Tan & Libido (Melanotan II)A melanocortin stack pairing Melanotan II for tanning with PT-141 for libido — same receptor family, two effects.2 compounds