IllumiNeuro Protocol
Also known as: IllumiNeuro, Neuro Stack
Four-Peptide Cognitive Enhancement Blend
Overview
IllumiNeuro is a cognitive enhancement peptide blend combining four nootropic peptides: PE-22-28 (neuritogenic), Pinealon (pineal bioregulator), NA-Semax Amidate (neuroprotective/cognitive), and NA-Selank Amidate (anxiolytic/cognitive). The standard formulation contains 48mg total (PE-22-28 10mg + Pinealon 10mg + NA-Semax 20mg + NA-Selank 8mg). This blend targets multiple neurological pathways for comprehensive cognitive support, though no clinical studies exist on this specific four-peptide combination.
Key benefits
- Multi-pathway cognitive enhancement
- Neuroprotective and neuritogenic effects
- Anxiolytic properties from NA-Selank
- BDNF upregulation from NA-Semax
- Circadian/sleep support from Pinealon
- Convenience of single injection
- Extended-action amidate forms included
Mechanism of action
Each peptide contributes distinct neurological mechanisms: PE-22-28 promotes neurite outgrowth and neural connectivity through sphingosine-1-phosphate receptor modulation; Pinealon is a bioregulator that supports pineal gland function and circadian regulation; NA-Semax Amidate provides BDNF upregulation and neuroprotection; NA-Selank Amidate offers anxiolytic effects through GABA modulation and immune-neuroendocrine regulation. Together, they theoretically address cognitive enhancement, neuroprotection, mood support, and neural regeneration.
Molecular data
- Type
- Fixed-ratio peptide combination
Sequence
PE-22-28 + Pinealon + NA-Semax + NA-Selank
Blend composition
What is in the vial, and in what proportion. Each component has its own reference page.
Total 48 mg per vial.
Indications
What the research community uses this compound for, with self-reported effectiveness.
Cognitive Enhancement
Memory & Learning
EffectiveCombined BDNF support and neuritogenic effects may enhance memory formation and learning.
Focus & Concentration
EffectiveNA-Semax component supports sustained attention and mental clarity.
Neuroprotection
ModerateMultiple pathways protecting neural tissue from oxidative stress and damage.
Mood & Anxiety
Anxiety Reduction
EffectiveNA-Selank provides anxiolytic effects through GABA modulation.
Stress Adaptation
ModerateImmune-neuroendocrine support helps with stress resilience.
Mood Support
ModerateCombined effects on neurotransmitter systems may improve overall mood.
Neural Health
Neurite Outgrowth
ModeratePE-22-28 promotes neural connectivity and neurite extension.
Circadian Regulation
ModeratePinealon supports healthy sleep-wake cycles and pineal function.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Injectable
Subcutaneous injection is the standard delivery method. Some users also administer intranasally for more direct CNS effects. Amidate forms (NA-Semax and NA-Selank) have enhanced stability and duration.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Conservative cognitive support | 100-200mcg total blend | Once daily (morning) | SubQ or intranasal |
| Standard protocol | 200-400mcg total blend | Once daily | SubQ |
| Enhanced protocol | 400-500mcg total blend | Once daily | SubQ |
Preparation
You will need
- IllumiNeuro 48mg vial
- Bacteriostatic water (2-4mL)
- Insulin syringes
- Alcohol prep pads
Steps
- Clean vial top with alcohol pad
- Add 2mL bacteriostatic water (creates 24mg/mL)
- Gently swirl - do not shake
- Solution should appear clear
- Label with date and concentration
- Store refrigerated immediately
- Use within 4 weeks
Work out the water volume and syringe units in the reconstitution calculator →
Nasal
Intranasal delivery provides more direct access to the CNS. The component peptides (especially Semax and Selank) have established intranasal protocols.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Intranasal cognitive | 100-300mcg | Once or twice daily | Intranasal spray |
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
NA-Semax (standalone)
AvoidAlready contains NA-Semax - do not add more to avoid overdosing.
NA-Selank (standalone)
AvoidAlready contains NA-Selank - do not add more.
Pinealon (standalone)
AvoidAlready contains Pinealon.
Dihexa
MonitorBoth highly neuroactive; use caution combining multiple cognitive enhancers.
Stimulants
MonitorThe blend has stimulatory cognitive effects; monitor if combining with other stimulants.
Epitalon
CompatibleComplementary pineal/longevity support; different mechanisms.
BPC-157
CompatibleDifferent targets; BPC-157 may complement with healing/gut-brain effects.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- Days 1-3
NA-Semax/Selank effects may be noticeable quickly (focus, anxiety reduction)
- Week 1-2
Cognitive enhancement and mood effects develop
- Week 2-4
Neuritogenic and BDNF effects building
- Week 4-8
Full protocol benefits; assess and cycle off
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Injection site reactions (mild)
- Nasal irritation if used intranasally
- Possible vivid dreams (Pinealon effect)
- Mild headache initially
Rare side effects
- Overstimulation or anxiety (paradoxical)
- Sleep changes
Stop signs — stop and seek advice
- Severe headaches
- Significant mood changes
- Allergic reactions
- Cognitive impairment instead of enhancement
Contraindications
- No clinical trials on four-peptide combination
- Bipolar disorder or psychosis (caution with cognitive enhancers)
- Pregnancy or breastfeeding
- Seizure disorders (theoretical concern)
Monitoring
- Cognitive function and focus
- Mood and anxiety levels
- Sleep quality
- Any unusual neurological symptoms
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- Third-party testing confirming all four components
- Certificate of Analysis with ratios verified
- Reputable research supplier
- Proper cold chain shipping
Warning signs
- Research-only status - not approved for human use
- Complex four-peptide formulation may have batch variability
Stop signs — don't use
- No Certificate of Analysis
- Cannot verify component ratios
- Suspiciously low pricing
References
Primary literature and clinical-trial data informing this entry.
PE-22-28 Neuritogenic Effects
Neuroscience Research
PE-22-28 promotes neurite outgrowth through S1P receptor modulation.
NA-Semax Amidate Cognitive Enhancement
Multiple Studies
Enhanced stability amidate form of Semax with BDNF upregulation and neuroprotective effects.
NA-Selank Amidate Anxiolytic Properties
Pharmacological Research
Selank demonstrates anxiolytic effects through GABA modulation and immune-neuroendocrine regulation.
Pinealon Bioregulator
Russian Medical Literature
Pinealon (EDR tripeptide) supports pineal gland function and circadian regulation.
Last updated . How this page was sourced is described in the methodology.