Ovagen
Also known as: EDL, Glu-Asp-Leu, Liver Tripeptide, GI Bioregulator
EDL Tripeptide | Liver & GI Bioregulator
Overview
Ovagen is a Khavinson bioregulator tripeptide (EDL) with primary effects on the liver and gastrointestinal tract. Developed by Dr. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it reduces long-term liver fibrosis and protects the GI mucosal layer from antibiotics, environmental toxins, and chemotherapy. Like other bioregulators, Ovagen crosses cell and nuclear membranes to directly regulate DNA transcription patterns with tissue-specific effects.
Key benefits
- Reduces long-term liver fibrosis
- Protects GI mucosal layer
- Defense against antibiotic damage
- Protection from environmental toxins
- May protect against chemotherapy GI effects
- Tissue-specific targeting via PEPT transporters
- Direct DNA regulation
- Part of comprehensive anti-aging protocols
Mechanism of action
Ovagen works through epigenetic regulation by crossing cell and nuclear membranes to directly regulate DNA structure and transcription patterns. It is transported into cells via POT family transporters (PEPT1, PEPT2) that specifically handle di- and tripeptides, explaining its precise tissue targeting. The peptide has tissue-specific effects on liver and GI tract, reducing fibrosis and protecting mucosal integrity.
Molecular data
- Type
- Tripeptide bioregulator
- Formula
- C15H25N3O8
- Half-life
- Not established
Sequence
Glu-Asp-Leu
Indications
What the research community uses this compound for, with self-reported effectiveness.
Liver Support
Liver Fibrosis
EffectiveReduces long-term fibrosis development in liver tissue.
Hepatoprotection
ModerateProtects liver through gene expression regulation.
GI Protection
Mucosal Protection
EffectiveHelps protect GI mucosal layer from various insults.
Antibiotic Recovery
ModerateMay protect GI tract from antibiotic-induced damage.
Toxin Defense
ModerateProtects against environmental toxin effects on GI tract.
Anti-Aging
Liver Aging
ModerateAddresses age-related liver changes through bioregulation.
GI Aging
ModerateSupports GI tract function during aging.
Dosing protocols
Common protocols by delivery method. Adjust the curve below to model accumulation in your own cycle.
Oral
Available in capsule form for oral administration. As a tripeptide, Ovagen is transported via PEPT1/PEPT2 transporters for targeted delivery to liver and GI tissue. Typical protocol involves 10-20 day cycles.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Standard protocol | 10-20 mg | Daily for 10-20 days | Oral capsules |
| Maintenance | 10 mg | 2-3 cycles yearly | Oral capsules |
Injectable
Injectable form available for direct administration.
| Protocol | Dose | Frequency | Route / duration |
|---|---|---|---|
| Research protocol | 10 mg | Daily for 10 days | IM or SubQ |
Preparation
You will need
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs
- Sterile vial
Steps
- Clean work area thoroughly
- Reconstitute with appropriate volume
- Gently swirl until dissolved
- Store reconstituted solution refrigerated
Work out the water volume and syringe units in the reconstitution calculator →
Interactions
Pairwise interactions with other compounds you might be cycling — the same data behind the cycle builder's safety check.
Livagen
SynergisticComplementary liver bioregulators with different sequences and mechanisms.
Glutathione
SynergisticBoth support liver health through different pathways.
Epitalon
SynergisticOften combined in comprehensive anti-aging Khavinson protocols.
BPC-157
CompatibleBoth support GI health; different mechanisms.
Timeline
Typical week-by-week effects reported in clinical and observational data.
- During cycle
Gene expression modulation begins
- Post-cycle
Effects persist due to epigenetic changes
- Weeks-Months
Liver and GI function improvements
- Long-term
Cumulative benefits with periodic cycles
Safety
Reported adverse effects, contraindications, and what to monitor on cycle.
Common side effects
- Generally well-tolerated
- Minimal side effects reported
Rare side effects
- Allergic reactions (rare)
Stop signs — stop and seek advice
- Allergic reactions
- Unusual GI or liver symptoms
Contraindications
- Active liver emergencies (seek medical care)
- Known hypersensitivity
- Pregnancy or breastfeeding
Quality checks
What a legitimate product looks like, what should give pause, and what should make you stop.
Good signs
- White powder or capsules
- Clear solution if reconstituted
- Proper packaging and labeling
Warning signs
- Unknown source or purity
- Do not confuse with FSH derivative of same name
Stop signs — don't use
- Discoloration
- Unusual odor
- Damaged packaging
References
Primary literature and clinical-trial data informing this entry.
Khavinson Peptide Bioregulators Overview
Advances in Gerontology · 2020
Ovagen (EDL) is a tripeptide bioregulator with effects on liver and GI tract.
POT Family Transporters and Peptide Bioregulators
Drug Metabolism Reviews · 2018
Di- and tripeptides are transported via PEPT1/PEPT2, explaining tissue-specific targeting.
Peptide Bioregulators and Liver Fibrosis
Experimental Gerontology · 2019
Short peptides reduce long-term fibrosis in liver tissue through gene expression regulation.
Last updated . How this page was sourced is described in the methodology.