Goals · Systems & Longevity
Protection against neurodegeneration, neuroinflammation, and neuroplasticity maintenance.
Compounds linked to this goal in the catalogue, ordered by role — primary, then support, then optional. Roles follow peptide-db's per-use effectiveness rating (most effective → primary, effective → support, moderate or thinner → optional); a compound that reaches the goal through a curated stack or a condition page says so. Click any card for the full mechanism, dosing, and evidence.
Tissue-Protective Peptide | Innate Repair Receptor Agonist
Half-life: ~20 minutes (SubQ), ~2 minutes (IV)
Neuropeptide Preparation | Neurological Recovery
Half-life: Minutes (component-dependent; e.g., BDNF ~10 min)
Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement
Half-life: Not established
N-Acetyl Selank Amidate | Enhanced Tuftsin Analog
Half-life: Not established
Support — BDNF Upregulation · effective
Next-Generation Semax Derivative | Nootropic Neuropeptide
Half-life: 8-10 hours
Support — Stroke Recovery · effective
AEDP | Brain Cortex Bioregulator Peptide
Half-life: Minutes (short peptide); effects persist via epigenetic changes
Support — Ischemic Brain Injury Recovery · effective
IGF-1 Bioavailability Regulator & Neuroprotective Peptide
Half-life: Extended stability (more stable than linear GPE precursor)
Support — Cognitive Enhancement · effective
Synaptogenic Peptide | Cognitive Enhancement
Half-life: 8-12 days
Support — Amyloid Reduction · effective
GDNF-Derived Peptide | Dopaminergic Neuroprotection
Half-life: Not well characterized
Support — Dopaminergic Neuron Protection · effective
Synthetic Pineal Tetrapeptide | Telomerase Activator
Half-life: Not established (short peptide)
Support — Pineal Function Restoration · effective
Mitochondria-Derived Peptide | HN
Half-life: ~30 minutes (mice), >4 hours (rats)
Support — Alzheimer's Disease Protection · effective
Enhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection
Half-life: 2-10 hours
Support — Stroke Recovery Support · effective
N-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic
Half-life: 4-6 hours
Support — Curated stack: Cognition & Neuro Support
P021 | CNTF-Derived Neurogenic Peptide
Half-life: Over 3 hours (mouse plasma)
Support — Alzheimer's Disease · effective
Synthetic ACTH Analog | Nootropic & Neuroprotective Peptide
Half-life: 0.5-2 hours
Support — Stroke Recovery · effective
Body Protection Compound-157 | Pentadecapeptide
Half-life: <30 minutes
Optional — Neuroprotection · moderate
NCAM-Derived Peptide | Synaptic Plasticity & Neuroprotection
Half-life: Not well characterized
Optional — Stroke Recovery · moderate
L-Glutathione | Master Antioxidant Tripeptide
Half-life: ~10-14 minutes (IV)
Optional — Parkinson's Disease Support · moderate
Four-Peptide Cognitive Enhancement Blend
Optional — Neurite Outgrowth · moderate
Essential Cellular Coenzyme & Anti-Aging Therapy
Half-life: 1-4 hours (intracellular)
Optional — Cognitive Enhancement · moderate
Thymosin β4 · 43-amino-acid regenerative peptide
Half-life: ~2 hours
Optional — Neuroprotection · moderate
FTS | Zinc-Dependent Thymic Nonapeptide
Half-life: ~10 minutes (free form); extended with nanoparticle formulations
Optional — HPA Axis Modulation · moderate
Vasoactive Intestinal Peptide | Neuropeptide
Half-life: 1-2 minutes
Optional — Neuroprotection · moderate
No SARMs tagged for this goal yet.
Chelated Magnesium | Sleep, Recovery & Cardiovascular Support
Half-life: ~30 hours (whole-body); urinary excretion is the primary regulator
Support — Migraine Prophylaxis · effective
Mucolytic | Glutathione Precursor | FDA-Approved Drug
Half-life: ~6 hours (oral); plasma cysteine elevation persists ~12 hours
Support — Curated stack: Neuro Focus (Semax)
GABA-B Agonist | Anxiolytic & Sleep Aid
Half-life: ~5 hours
Support — Generalized Anxiety · effective
Beta-Carboline | Dopaminergic Neurorestorative
Half-life: Not well characterized in humans
Optional — Parkinson's Disease (Preclinical) · moderate
Phosphocreatine Precursor | Most-Researched Sports Supplement
Half-life: ~3 hours (plasma); muscle saturation reached over 4 weeks at maintenance dose
Optional — Traumatic Brain Injury (Adjunct) · under research
Mitochondrial Electron Carrier | Cognitive & Neuroprotection
Half-life: ~5-6 hours
Optional — Alzheimer's Disease · emerging
Eugeroic | Wakefulness & Cognitive Enhancement
Half-life: ~12-15 hours
Optional — Researched for Brain Fog
NAD+ Precursor | Cellular Energy & Longevity
Half-life: ~2-3 hours (oral)
Optional — Cognitive Support · moderate
mTOR Inhibitor | Longevity & Immunosuppression
Half-life: ~62 hours
Optional — Researched for Age-Related Cognitive Decline
DHT Derivative | Mood, Libido & Muscle Hardening
Half-life: ~12 hours
Support — Mood and Well-Being · effective
Anabolic-Androgenic Steroid | Primary Male Sex Hormone
Half-life: ~8 days (cypionate)
Support — Energy and Vitality · effective